Statement of Changes of Beneficial Ownership

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0287 Expires: January 31, 2008 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(f) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^* GOLDBERG MURRAY A	2. Issuer Name and Ticker or Trading Symbol REGENERON PHARMACEUTICALS INC [ REGN ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner __ X __ Officer (give title below) _____ Other (specify below) SVP Fin & Admin, CFO, & Treas
(Last) (First) (Middle) 777 OLD SAW MILL RIVER RD	3. Date of Earliest Transaction (MM/DD/YYYY) 12/23/2005
(Street) TARRYTOWN, NY 10591 (City) (State) (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _ X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common Stock	12/23/2005		M/K ⁽¹⁾		1000	A	$12.750	37516	D
Common Stock	12/23/2005		S/K ⁽¹⁾		1000	D	$12.990	36516	D
Common Stock	12/23/2005		M/K ⁽¹⁾		1000	A	$12.750	37516	D
Common Stock	12/23/2005		S/K ⁽¹⁾		1000	D	$13.000	36516	D
Common Stock	12/23/2005		M/K ⁽¹⁾		1000	A	$12.750	37516	D
Common Stock	12/23/2005		S/K ⁽¹⁾		1000	D	$13.050	36516	D
Common Stock	12/23/2005		M/K ⁽¹⁾		100	A	$12.750	36616	D
Common Stock	12/23/2005		S/K ⁽¹⁾		100	D	$13.080	36516	D
Common Stock	12/23/2005		M/K ⁽¹⁾		700	A	$12.750	37216	D
Common Stock	12/23/2005		S/K ⁽¹⁾		700	D	$13.090	36516	D
Common Stock	12/23/2005		M/K ⁽¹⁾		4200	A	$12.750	40716	D
Common Stock	12/23/2005		S/K ⁽¹⁾		4200	D	$13.100	36516	D
Common Stock	12/23/2005		M/K ⁽¹⁾		1804	A	$12.750	38320	D
Common Stock	12/23/2005		S/K ⁽¹⁾		1804	D	$13.110	36516	D
Common Stock	12/23/2005		M/K ⁽¹⁾		1100	A	$12.750	37616	D
Common Stock	12/23/2005		S/K ⁽¹⁾		1100	D	$13.120	36516	D
Common Stock	12/23/2005		M/K ⁽¹⁾		246	A	$12.750	36762	D
Common Stock	12/23/2005		S/K ⁽¹⁾		246	D	$13.130	36516	D
Common Stock	12/23/2005		M/K ⁽¹⁾		1000	A	$12.750	37516	D
Common Stock	12/23/2005		S/K ⁽¹⁾		1000	D	$13.160	36516	D
Common Stock	12/23/2005		M/K ⁽¹⁾		17850	A	$12.750	54366	D
Common Stock	12/23/2005		F/K ⁽¹⁾		17098	D	$13.310	37268	D
Common Stock	12/23/2005		F/K ⁽¹⁾		260	D	$13.310	37008	D
Common Stock	12/27/2005		S/K ⁽¹⁾		492	D	$14.94	36516	D

*Table II - Derivative Securities Beneficially Owned ( e.g.* , puts, calls, warrants, options, convertible securities)**
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)			11. Nature of Indirect Beneficial Ownership (Instr. 4)
Incentive Stock Option (right to buy)	$12.750	12/23/2005		M/K ⁽¹⁾			1000	⁽²⁾	1/2/2006	Common Stock	1000	$0.00	11150	D
Incentive Stock Option (right to buy)	$12.750	12/23/2005		M/K ⁽¹⁾			1000	⁽²⁾	1/2/2006	Common Stock	1000	$0.00	10150	D
Incentive Stock Option (right to buy)	$12.750	12/23/2005		M/K ⁽¹⁾			1000	⁽²⁾	1/2/2006	Common Stock	1000	$0.00	9150	D
Incentive Stock Option (right to buy)	$12.750	12/23/2005		M/K ⁽¹⁾			100	⁽²⁾	1/2/2006	Common Stock	100	$0.00	9050	D
Incentive Stock Option (right to buy)	$12.750	12/23/2005		M/K ⁽¹⁾			700	⁽²⁾	1/2/2006	Common Stock	700	$0.00	8350	D
Incentive Stock Option (right to buy)	$12.750	12/23/2005		M/K ⁽¹⁾			4200	⁽²⁾	1/2/2006	Common Stock	4200	$0.00	4150	D
Incentive Stock Option (right to buy)	$12.750	12/23/2005		M/K ⁽¹⁾			1804	⁽²⁾	1/2/2006	Common Stock	1804	$0.00	2346	D
Incentive Stock Option (right to buy)	$12.750	12/23/2005		M/K ⁽¹⁾			1100	⁽²⁾	1/2/2006	Common Stock	1100	$0.00	1246	D
Incentive Stock Option (right to buy)	$12.750	12/23/2005		M/K ⁽¹⁾			246	⁽²⁾	1/2/2006	Common Stock	246	$0.00	1000	D
Incentive Stock Option (right to buy)	$12.750	12/23/2005		M/K ⁽¹⁾			1000	⁽²⁾	1/2/2006	Common Stock	1000	$0.00	0	D
Non-Qualified Stock Option (right to buy)	$12.750	12/23/2005		M/K ⁽¹⁾			17850	⁽²⁾	1/2/2006	Common Stock	17850	$0.00	0	D

Explanation of Responses:
( 1)	Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).
( 2)	Exercisable date, exercise date, exercise price, purchase price, sales price, and/or expiration date is not applicable in this case.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
GOLDBERG MURRAY A 777 OLD SAW MILL RIVER RD TARRYTOWN, NY 10591			SVP Fin & Admin, CFO, & Treas

Signatures
By: /s/ Stuart Kolinski For: /s/ Murray A. Goldberg		12/28/2005
^** Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:	File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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POWER OF ATTORNEY

Know all by these presents,
that the undersigned hereby constitutes and appoints each of Leonard
Schleifer, , Beverly Dubs, Stuart Kolinski, Murray Goldberg, and Douglas
McCorkle signing singly, the undersigned's true and lawful

attorney-in-fact to:

(1) execute for and on behalf of the undersigned in the undersigned's capacity as a director of Regeneron Pharmaceuticals, Inc. (the "Company"), Forms 3, 4, and 5 in accordance with Section 16(a) of the Securities Exchange Act of 1934 and the rules thereunder;

(2) do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to complete and execute any such Form 3, 4, or 5, complete and execute any amendment or amendments thereto, and timely file such form with the United States Securities and Exchange Commission and any stock exchange or similar authority; and

(3) take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit to, in the best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-act on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain such terms and conditions as such attorney-in-fact may approve in such attorney-in-fact's discretion.

The undersigned hereby grants to each such attorney-in-fact full power and
authority to do and perform any and every act and thing whatsoever requisite,
necessary, or proper to be done in the exercise of any of the rights and powers
herein granted, as fully to all intents and purposes as the undersigned might or
could do if personally present, with
full power of substitution or revocation, hereby ratifying and confirming
all that such attorney-in-fact, or such
attorney-in-fact's substitute or
substitutes, shall lawfully do or cause to be done by virtue of this
power of attorney and the rights and powers herein granted. The
undersigned acknowledges that the foregoing attorneys-in-fact, in serving
in such capacity at the request of the undersigned, are not assuming, nor
is the Company assuming, any of the undersigned's responsibilities to comply
with Section 16 of the Securities Exchange Act of 1934.

This Power of Attorney shall remain in full force and effect until the

undersigned is no longer required to file Forms 3, 4, and 5 with respect to the
undersigned's holdings of and transactions in securities issued by the Company,
unless earlier revoked by the undersigned in a signed writing delivered to the
foregoing attorneys-in-fact.

IN WITNESS
WHEREOF, the undersigned has caused this Power of Attorney to be executed
as of this 12th day of September, 2005.

                                                                **/s/Murray A.
Goldberg
                                                                -----------------------
                                                                Signature

Murray A. Goldberg
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