Definitive Proxy Statement


 
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
 
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IDENIX PHARMACEUTICALS, INC.
(Name of Registrant as Specified In Its Charter)
 

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)
 
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Dear Idenix Stockholder:
 
Please join us for the 2010 Annual Meeting of Stockholders of Idenix Pharmaceuticals, Inc. The annual meeting will be held on Thursday, June 3, 2010 at 9:00 a.m., at the offices of WilmerHale, located at 60 State Street, Boston, Massachusetts 02109.
 
At this year’s annual meeting, we will consider and act upon the following matters:

 
1.
To elect nine directors;

 
2.
To ratify the appointment of our independent registered public accounting firm;

 
3.
To approve an amendment to our 2005 Stock Incentive Plan increasing the number of shares of common stock authorized for issuance thereunder from 6,000,000 to 9,000,000 shares; and

 
4.
To transact any other business that may properly come before the meeting.
 
Additional information about the items of business to be discussed at our annual meeting is given in the attached Notice of Annual Meeting and Proxy Statement.
 
I urge you to carefully review the proxy materials and to vote FOR the election of the director nominees, FOR ratification of the appointment of our independent registered public accounting firm, and FOR the amendment to our 2005 Stock Incentive Plan.
 
On behalf of the Idenix board of directors, employees and management, I thank you for your support and confidence. We look forward to seeing you at the annual meeting.
 
Very truly yours,
 
JEAN-PIERRE SOMMADOSSI
 Chairman and Chief Executive Officer
 
April 30, 2010

 
 

 

IDENIX PHARMACEUTICALS, INC.
60 Hampshire Street
Cambridge, Massachusetts 02139
 
NOTICE OF 2010 ANNUAL MEETING OF STOCKHOLDERS
 
     
Date
 
June 3, 2010
     
Time
 
9:00 a.m. (eastern daylight time)
     
Place
 
WilmerHale
 60 State Street
 Boston, Massachusetts 02109
     
Items of Business
 
1. To elect nine directors to serve until the next annual meeting of stockholders and until their successors are elected and qualified;
     
   
2. To ratify the selection of PricewaterhouseCoopers LLP as our independent registered public accounting firm for the current fiscal year ending December 31, 2010;
     
   
3. To approve an amendment to our 2005 Stock Incentive Plan increasing the number of shares of common stock authorized for issuance thereunder from 6,000,000 to 9,000,000 shares; and
     
   
4. To transact such other business as may properly come before the meeting or any adjournment thereof.
     
Record Date
 
You are entitled to notice of, and to vote at the annual meeting and any adjournments of that meeting, if you were a stockholder of record at the close of business on April 9, 2010.
     
Voting by Proxy
 
Please submit the enclosed proxy as soon as possible so that your shares can be voted at the annual meeting in accordance with your instructions. For specific instructions regarding voting, please refer to the Questions and Answers beginning on page 1 of the Proxy Statement and the instructions on your proxy card.
     
   
Submitting your proxy will not affect your right to attend the meeting and vote. A stockholder who gives a proxy may revoke it at any time before it is exercised by voting in person at the annual meeting, by delivering a subsequent proxy or notifying the inspector of elections in writing of such revocation.
 
By Order of the Board of Directors,
 
John F. Weidenbruch,  Secretary
Cambridge, Massachusetts
April 30, 2010

 
 

 

TABLE OF CONTENTS
PROXIES AND VOTING
 
1
Householding of Annual Meeting Materials
 
4
PROPOSAL 1 — ELECTION OF DIRECTORS
 
4
DIRECTOR COMPENSATION
 
9
CORPORATE GOVERNANCE
 
11
Corporate Governance Guidelines
 
11
Director Independence
 
11
Meetings of Independent Directors
 
11
Director Attendance at Annual Meetings of Stockholders
 
11
Board of Directors
 
11
Board Leadership Structure
 
12
Committees of Our Board of Directors
 
12
Information About Our Nominating Process
 
13
Director Qualification Standards
 
14
Communicating with the Board of Directors
 
14
Policy on Business Conduct and Ethics
 
15
Oversight of Risk
 
15
SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
 
15
Beneficial Ownership Table
 
15
Executive Officers
 
17
COMPENSATION DISCUSSION AND ANALYSIS
 
18
Executive Summary
 
18
Overview of Our Philosophy and Procedures for Determining Executive Compensation
 
18
Review of Management’s Actual Performance Compared to Pre-Determined Goals
 
20
2009 Corporate Objectives
 
21
Components of Our Executive Compensation Program
 
22
Stock Option Grant Practices
 
25
Stock Option Grants for Fiscal 2009 and Target Grants for Fiscal 2010
 
26
Benefits
 
26
Severance and Change-in-Control Payments
 
27
Tax Considerations
 
28
Summary
 
28
EXECUTIVE COMPENSATION
 
29
Compensation Summary
 
29
Grants of Plan-Based Awards
 
30
Outstanding Equity Awards at Fiscal Year-End
 
31
Option Exercises and Stock Vested
 
32
Potential Payments Upon Termination or Change in Control
 
33
Compensation Committee Interlocks and Insider Participation
 
34
Equity Compensation Plan Information
 
34
 COMPENSATION COMMITTEE REPORT
 
35
 AUDIT COMMITTEE REPORT
 
36
CERTAIN RELATIONSHIPS AND RELATED PERSON TRANSACTIONS
 
37
Policies and Procedures for Related Person Transactions
 
37
Relationship with Novartis Pharma AG
 
38
Employment Agreements
 
41
Registration Rights
 
42
PROPOSAL 2 — RATIFICATION OF SELECTION OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
 
43
Principal Accounting Fees and Services
 
43
Pre-Approval Policies and Procedures
 
43
PROPOSAL 3 – APPROVAL OF AMENDMENT TO 2005 STOCK INCENTIVE PLAN
 
44
OTHER INFORMATION
 
49
Other Matters
 
49
Section 16(a) Beneficial Ownership Reporting Compliance
 
49
Stockholder Proposals for 2010 Annual Meeting
 
49
APPENDIX A — 2005 Stock Incentive Plan and Amendment No. 1 and Amendment No. 2
 
50

 
 

 
 
IDENIX PHARMACEUTICALS, INC.
 
60 Hampshire Street
Cambridge, Massachusetts 02139
 
Proxy Statement for the 2010 Annual Meeting of Stockholders
To Be Held on June 3, 2010
 
PROXIES AND VOTING
 
This proxy statement contains information about the 2010 annual meeting of stockholders of Idenix Pharmaceuticals, Inc. We are holding the meeting on Thursday, June 3, 2010 at 9:00 a.m. (eastern daylight time) at the offices of WilmerHale, 60 State Street, Boston, Massachusetts 02109.
 
Directions to the offices of WilmerHale, 60 State Street, Boston, Massachusetts 02109 are available at the WilmerHale website at http://www.wilmerhale.com/offices/offices/visitingus.aspx?officeid=1 .
 
In this proxy statement, references to “Idenix”, “we”, “us” and “our” refer to Idenix Pharmaceuticals, Inc.
 
IMPORTANT NOTICE REGARDING THE AVAILABILITY OF PROXY MATERIALS
 FOR THE 2010 ANNUAL MEETING OF STOCKHOLDERS TO BE HELD ON JUNE 3, 2010
 
This proxy statement and the Annual Report on Form 10-K for the year ended December 31, 2009 are available for viewing, printing and downloading at http://www.idenix.com/InvestorRelations/2010proxy and www.edocumentview.com/IDIX .
 
Additionally, you can find our Annual Report on Form 10-K for the year ended December 31, 2009 through the Securities and Exchange Commission’s electronic data system, called EDGAR, at www.sec.gov. You may obtain additional printed copies of our Annual Report on Form 10-K, free of charge, by sending a written request to: Idenix Pharmaceuticals, Inc., attention: Investor Relations, 60 Hampshire Street, Cambridge, Massachusetts 02139. Exhibits will be provided upon written request and payment of an appropriate processing fee.
 
    The notice of annual meeting, this proxy statement and our annual report to stockholders (which includes our annual report on Form 10-K for the year ended December 31, 2009), are being mailed to stockholders on or about April 30, 2010.
 
References to our website are inactive textual references only and the contents of our website should not be deemed to be incorporated by reference into this proxy statement.
 
Q.
Who can vote at the annual meeting?
 
A.
To be able to vote, you must have been a stockholder of record at the close of business on April 9, 2010, the record date for our annual meeting. On that date, 66,373,742 shares of common stock were issued and outstanding and entitled to vote at the annual meeting.
 
 
If you were a stockholder of record on that date, you are entitled to vote all of the shares that you held on that date at the annual meeting, or any postponements or adjournments of the annual meeting.
 
Q.
What are the voting rights of the holders of common stock?
 
A.
Each outstanding share of our common stock entitles the holder to one vote on each proposal considered at the annual meeting. We have no other securities authorized which would entitle a holder to vote at the meeting.

 
1

 

Q.
What is a proxy card?

A.
The proxy card enables you to appoint Jean-Pierre Sommadossi, our chief executive officer, and John Weidenbruch, our executive vice president and general counsel, as your representatives at the annual meeting. By completing and returning the proxy card, you are authorizing Dr. Sommadossi or Mr. Weidenbruch to vote your shares at the meeting as you have instructed on the proxy card. If you do not specify on the proxy card how your shares should be voted, they will be voted as recommended by our board of directors. By returning the proxy card to us, you can vote your shares whether or not you attend the meeting.

Q.
What am I voting on?

A.
We are asking you to vote on:

the election of directors for a one-year term;

the ratification of PricewaterhouseCoopers LLP as our independent registered public accounting firm for the current fiscal year ending December 31, 2010; and

an amendment to our 2005 Stock Incentive Plan increasing the number of shares of common stock authorized for issuance thereunder from 6,000,000 to 9,000,000.

Q.
How do I vote?

A.
If you are a record holder, meaning your shares are registered in your name, you may vote:

(1)  By Mail:   Complete, date and sign the enclosed proxy card and mail it in the enclosed postage paid envelope. Your shares will be voted according to your instructions. If you do not specify how your shares should be voted, they will be voted as recommended by our board of directors.

(2)  In Person at the Meeting:   If you attend the meeting, you may deliver your completed proxy card in person or you may vote by completing a ballot, which we will provide to you at the meeting.

If your shares are held in “street name,” meaning they are held for you by a broker, bank or other nominee, you may vote:

(1)  By Mail:   You will receive instructions from your broker, bank or other nominee explaining how you can vote your shares by mail. You should follow those instructions.

(2)  In Person at the Meeting:   Contact the broker, bank or other nominee who holds your shares to obtain a proxy card and bring it with you to the meeting.   You will not be able to vote in person at the meeting unless you have obtained from the broker, bank or other nominee a proxy issued in your name giving you the right to vote your shares.

Q.
How may I change or revoke my proxy?

A.
You may change or revoke your proxy at any time before the meeting. To do so, you must do one of the following:

 
(1)
Provide written notice to us in time for receipt prior to the meeting that you wish to revoke your proxy. Such notice should be sent to us c/o Secretary, Idenix Pharmaceuticals, Inc., 60 Hampshire Street, Cambridge, Massachusetts 02139.

 
(2)
Sign a new proxy and submit it to us c/o Secretary, Idenix Pharmaceuticals, Inc., 60 Hampshire Street, Cambridge, Massachusetts 02139 in time for receipt prior to the meeting. Only the most recently dated proxy will be counted.

 
(3)
Attend the meeting, request that your proxy be revoked and vote in person as instructed above. Attending the meeting will not revoke your proxy unless you specifically request such revocation.

 
2

 

Q.
Will my shares be voted if I do not return my proxy?
 
 
A.
If your shares are registered directly in your name , your shares will not be voted if you do not vote either by returning your proxy or voting in person by ballot at the meeting.

If your shares are held in “street name,” we encourage you to provide voting instructions to your broker, bank or other nominee by giving your proxy to them.  If you are the beneficial owner of shares held in “street name” by a broker, the broker, as the record holder of the shares, is required to vote those shares in accordance with your instructions.  If you do not give instructions to the broker, the broker will be entitled to vote the shares with respect to “discretionary” items, but will not be permitted to vote the shares with respect to “non-discretionary” items (resulting in a “broker non-vote”).  The ratification of the selection of PricewaterhouseCoopers is a “discretionary” item.  The election of directors and the approval of the amendment to our 2005 Stock Incentive Plan are “non-discretionary” items.

Q.
How many shares must be present to hold the meeting?

A.
To establish a quorum, a majority of our outstanding shares of common stock as of the record date must be present in person or by proxy at the meeting. The presence of a quorum is a prerequisite to holding and conducting business at the meeting.

Q.
What vote is required to approve each matter and how are votes counted?

A.
Proposal 1 — Election of Directors .  The nine nominees for director who receive the highest number of votes FOR election will be elected as directors. This is called a plurality. Abstentions are not counted for purposes of electing directors. If your shares are held by your broker in “street name” and you do not vote your shares, your broker may not vote your unvoted shares on Proposal 1.  You may:

• vote FOR all nominees;

• WITHHOLD your vote from all nominees; or

• vote FOR one or more nominees and WITHHOLD your vote from one or more of the others. Votes that are withheld will not be included in the vote tally for the election of directors and will not affect the results of the vote.

Proposal 2 — Ratification of Selection of Independent Registered Public Accounting Firm.   The affirmative vote of stockholders holding a majority of the votes cast on this proposal is required to ratify PricewaterhouseCoopers LLP as our independent registered public accounting firm for the year ending December 31, 2010. If your shares are held by your broker in “street name” and you do not vote your shares, your broker may vote your unvoted shares on Proposal 2.

If you vote to abstain on this Proposal 2, your shares will not be voted in favor of or against the proposal and will also not be counted as votes cast or shares voting on the proposal. As a result, voting to abstain will have no effect on the voting on the proposal.

Although stockholder approval of our Audit Committee’s selection of PricewaterhouseCoopers LLP as our independent registered public accounting firm is not required, we believe that our stockholders should have an opportunity to ratify this selection. If this proposal is not approved at the annual meeting, our Audit Committee will reconsider its selection of PricewaterhouseCoopers LLP.

Proposal 3 –   Approval of Amendment to the 2005 Stock Incentive Plan.   The affirmative vote of stockholders holding a majority of the votes cast on this proposal is required to approve the amendment of the 2005 Stock Incentive Plan.

If you vote to abstain on this Proposal 3, your shares will not be voted in favor of or against the proposal and will also not be counted as votes cast or shares voting on the proposal. As a result, voting to abstain will have no effect on the voting on the proposal. If your shares are held by your broker in “street name” and you do not vote your shares, your broker may not vote your unvoted shares on Proposal 3.

 
3

 

Proposal 4 — Other Matters.   If any other matters are properly presented at the meeting, the persons named in the accompanying proxy will have the discretion to vote, or otherwise act for you, in accordance with their judgment on the matter. As of the date of this proxy statement, we do not know of any other matters to be presented at the annual meeting.

We believe that Novartis Pharma AG, a direct and wholly owned subsidiary of Novartis AG, referred to herein collectively with their respective subsidiaries and affiliates as Novartis, intends to vote all of its shares FOR each proposal detailed above. On the record date, Novartis was the holder of approximately 47% of our outstanding common stock.

Q.
Where may I find the voting results?

A.
We will announce preliminary voting results at the meeting. We plan to report the final voting results on a Current  Report on Form 8-K  within four business days following the meeting.

Q.
Who is soliciting the proxy and what are the costs of soliciting these proxies?

A.
Our board of directors is soliciting the proxy accompanying this proxy statement. We will bear the cost of soliciting proxies. Our directors, officers and employees may solicit proxies by telephone, e-mail, facsimile and in person, without additional compensation. Upon request, we will also reimburse brokerage houses and other custodians, nominees and fiduciaries for their reasonable out-of-pocket expenses for distributing proxy materials.

Householding of Annual Meeting Materials

Some brokers, banks and other nominee record holders may be participating in the practice of “householding” proxy statements and annual reports. This means that only one copy of our proxy statement or annual report may have been sent to multiple stockholders in your household. We will promptly deliver a separate copy of either document to you if you call or write us at the following address or telephone number: 60 Hampshire Street, Cambridge, Massachusetts 02139, Attention: Investor Relations; 617-995-9800. If you want to receive separate copies of the annual report and proxy statement in the future, or if you are receiving multiple copies and would like to receive only one copy for your household, you should contact your broker, bank or other nominee record holder, or you may contact us at the above address and telephone number.

PROPOSAL 1 — ELECTION OF DIRECTORS

Our board of directors is elected each year at the annual meeting of stockholders. There are nine nominees for the nine currently authorized seats on our board of directors. Each director elected to hold office will do so until the 2011 annual meeting of stockholders and until her or his successor is elected and qualified, or until such director’s earlier death, resignation or removal. In February 2009, Dr. Emmanuel Puginier, a designee of Novartis, resigned from our board and was replaced by Dr. Steven Projan, also a designee of Novartis.  In June 2009, upon recommendation of the Nominating and Corporate Governance Committee of our board, our board elected Anthony Rosenberg, a Novartis designee, as a director. In connection with the election of Mr. Rosenberg, the number of authorized seats on our board of directors was increased from eight to nine.    On January 11, 2010, Pamela Thomas-Graham resigned from our board; Ms. Thomas-Graham had been a director of Idenix since 2005 and was recently named Chief Talent, Branding and Communications Officer of Credit Suisse and a member of the Executive Board of Credit Suisse.  On March 30 2010, upon recommendation of the Nominating and Corporate Governance Committee of our board of directors, our board of directors elected Tamar D. Howson as a director.
 
Each person nominated for election is currently serving as a director of Idenix.  The board of directors, upon the recommendation of the Nominating and Corporate Governance Committee, has nominated each of the listed nominees for election as a director. Steven Projan, Ph.D., Robert E. Pelzer and Anthony Rosenberg have been nominated as designees of Novartis, pursuant to the stockholders’ agreement and waiver and consent described under the caption “Certain Relationships and Related Party Transactions — Relationship with Novartis”. There are no family relationships among any of our directors and our executive officers.

Each nominee has agreed to serve if elected, and we do not know any reason why any nominee would be unable to serve. In the event that any nominee should be unavailable for election, proxies will be voted for the election of a substitute nominee designated by the board of directors or for election of only the remaining nominees.

Unless authority to do so is withheld, shares represented by executed proxies will be voted for the election of the nine nominees named below. Proxies cannot be voted for a greater number of persons than the number of nominees standing for election. Since nine directors are to be elected at the annual meeting, the nine nominees for director who receive the highest number of votes for election will be elected as directors.

 
4

 

Information with respect to the number of shares of common stock beneficially owned by each director as of April 1, 2010 appears under the heading “Security Ownership of Certain Beneficial Owners and Management”. The name, age, years of service on our board of directors, and principal occupation and business experience of each director nominee is set forth below.
 
Name and Age
 
Principal Occupation and Business Experience
 
Director Since
         
Jean-Pierre Sommadossi, Ph.D.
  (age 54)
 
Dr. Sommadossi is the principal founder of Idenix and has served as the chairman of our board of directors since our inception and as our president and chief executive officer since November 2000. During the period from November 1999 to November 2000, Dr. Sommadossi served as our executive president and chief scientific officer. Dr. Sommadossi served as a professor of pharmacology, toxicology and clinical pharmacology and associate director of both the Center for AIDS Research and the Liver Center, University of Alabama at Birmingham School of Medicine from June 1992 to November 2000. Dr. Sommadossi took a sabbatical and then unpaid leave from the University of Alabama at Birmingham from November 1999 to November 2002. From 1996 to 1999, Dr. Sommadossi served on the Research Agenda Committee of the AIDS Clinical Trial Group. Dr. Sommadossi holds a Pharm.D. and Ph.D. in Pharmacology from the University of Marseilles, France.
 
Dr. Sommadossi has overseen every aspect of our operations in his roles as chairman, president and chief executive officer.  We believe that he has an unparalleled understanding of our business, our scientific approach to research, and the markets in which we operate.
 
1998
         
Charles W. Cramb
 (age 63)
 
Mr. Cramb has served as the vice chairman, chief financial and strategic officer of The Avon Company, a global beauty products company, since September 2007. Mr. Cramb joined The Avon Company in November 2005 and previously served as executive vice president, finance and technology and chief financial officer. Prior to joining The Avon Company, Mr. Cramb served as the chief financial officer at The Gillette Company, a worldwide consumer products company, from July 1997 to November 2005. From July 1995 to July 1997, Mr. Cramb served as a corporate vice president and corporate controller of The Gillette Company. He is also a member of the board of directors of Tenneco Inc. Mr. Cramb holds a B.A. from Dartmouth College and an M.B.A. from the University of Chicago.
 
Mr. Cramb’s extensive financial leadership at his current and former companies adds vital expertise to our board of directors and to our Audit Committee in the form of financial understanding, business perspective and auditing expertise.   Mr. Cramb is diligent in keeping the board abreast of current audit issues and collaborating with our independent auditors and senior management team.
 
2003

 
5

 
 
Wayne T. Hockmeyer,
 Ph.D.
 (age 65)
 
Dr. Hockmeyer founded MedImmune, Inc., a biotechnology company, in April 1988 and served until October 2000 as the chief executive officer of MedImmune, Inc. Dr. Hockmeyer continued to serve as chairman of the board of directors of MedImmune, Inc. until June 2007.  From 2002 to 2007, Dr. Hockmeyer served as president of MedImmune Ventures, Inc., a wholly owned subsidiary of MedImmune, Inc. Dr. Hockmeyer also serves as a director of Baxter International, Inc. and GenVec, Inc. and has previously served as a director of Middlebrook Pharmaceutical Corporation. Dr. Hockmeyer was recognized, in 1998, by the University of Florida as a Distinguished Alumnus and in 2002 was awarded a Doctor of Science honoris causa from Purdue University. Dr. Hockmeyer holds a B.S. from Purdue University and a Ph.D. from the University of Florida.
 
Dr. Hockmeyer’s significant experience in establishing and maintaining strategic direction in the biotechnology and pharmaceutical industries is a key asset of our board of directors. He has tremendous insight into the drug development process and the scientific, operational and regulatory aspects of clinical trials.
 
2002
         
Thomas R. Hodgson
(age 68)
 
Mr. Hodgson, who is retired, served most recently, from September 1990 to January 1999, as president and chief operating officer of Abbott Laboratories, a pharmaceutical company. From 1983 to 1990, Mr. Hodgson served as the president of Abbott International and from 1978 to 1983, Mr. Hodgson served as the president of the Hospital Products Division of Abbott Laboratories. Mr. Hodgson is a director of The Travelers Companies Inc. and has previously served as a director of Intermune, Inc. Mr. Hodgson holds a B.S. from Purdue University, an M.S. from the University of Michigan, an M.B.A. from Harvard Business School and an honorary doctorate degree in engineering awarded by Purdue University.
 
With his extensive experience at the helm of a major health care company and his understanding of drug development, Mr. Hodgson provides an invaluable resource to our board of directors through his vital senior management experience and tested business acumen.
 
2002
         
Robert E. Pelzer
 (age 56)
 
Mr. Pelzer has served since September 2008 as president and chief executive officer of Novartis Corporation, a part of the Novartis Group, a multinational group of companies specializing in the research, development, manufacture, sale and distribution of innovative healthcare products. Prior to that, from March 2002 to August 2008, he served as general counsel of Novartis Pharmaceuticals Division, a part of Novartis Group. Prior to his appointment at Novartis in March 2002, Mr. Pelzer was general counsel at DuPont Pharmaceuticals Company from 1998 to December 2001. Prior to that time, Mr. Pelzer held various positions with The DuPont Company. Mr. Pelzer holds degrees in Commerce and in Law from the University of Alberta. He is admitted as barrister and solicitor in the Province of Alberta, Canada, and as Solicitor in England and Wales.
 
Mr. Pelzer serves on our board as one of three representatives of our largest stockholder, Novartis.  Mr. Pelzer’s experience in the industry provides our board with essential knowledge of the development and commercialization of pharmaceuticals.
 
2003

 
6

 

Denise Pollard-Knight,
 Ph.D.
 (age 50)
 
Dr. Pollard-Knight has served since April 2004 as head of Nomura Phase4 Ventures, an affiliate of Nomura International plc, a leading Japanese financial institution. From January 1999 to March 2004, Dr. Pollard-Knight served as head of Healthcare Private Equity at Nomura International plc. Dr. Pollard-Knight previously served as a director of Viacell.  From January 1997 to January 1999, Dr. Pollard-Knight was a member of Rothschild Asset Management Ltd., an investment management firm. Dr. Pollard-Knight holds a Ph.D. and BSc (Hons) from the University of Birmingham in England. Dr. Pollard-Knight completed postdoctorate work as a Fulbright Scholar at the University of California, Berkeley.
 
Dr. Pollard-Knight brings strong financial and investment skills and in-depth understanding of science to our board of directors.  Over her years on our board, these skills have allowed Dr. Pollard-Knight to provide vital contributions to our discussions regarding financing options, strategic collaborations and strategic direction of Idenix. Given her financial skills,  Dr. Pollard-Knight also brings a high level of expertise to the Audit Committee on which she serves.
 
2003
         
Steven Projan, Ph.D.
(age 57)
 
Dr. Projan has served as a director since February 2009. Dr. Projan has served since September 2008 as vice president, global head of infectious diseases for the Novartis Institute for Biomedical Research, Inc., a part of the Novartis Group. Prior to joining Novartis, from 1993 to August 2008, Dr. Projan held several positions at Wyeth Pharmaceuticals, including his most recent position as vice president of biological technologies. Dr. Projan holds a Ph.D. in molecular genetics from Columbia University.
 
Dr. Projan serves on our board as one of three representatives of our largest stockholder, Novartis.  With his diverse industry experience, Dr. Projan provides keen insight into the challenges and opportunities that exist in the biopharmaceutical space.
 
2009
         
Anthony Rosenberg
(age 56)
 
Mr. Rosenberg has served since 2005 as head of business development and licensing of Novartis Pharma AG, a part of the Novartis Group.  Prior to that Mr. Rosenberg was global head of the transplant and immunology business unit at Novartis from 2000 to 2005.  Mr. Rosenberg initially joined Sandoz, a predecessor to Novartis, in 1980.  Mr. Rosenberg is a member of the Pharma Executive Committee at Novartis Pharma AG.  Mr. Rosenberg holds a BSc from the University of Leicester and an M.Sc in physiology from the University of London.
 
Mr. Rosenberg serves on our board as one of three representatives of our largest stockholder, Novartis.  Through his experience at Novartis Pharma AG, Mr. Rosenberg is uniquely qualified to provide our board with industry-specific business development advice, further augmenting our board’s depth of expertise in this area. 
 
2009

 
7

 

Tamar D. Howson
(age 61 )
 
 
Ms. Howson is currently a Partner at JSB-Partners, a transaction advisory firm serving the life sciences industry.  Prior to joining JSB-Partners in 2010, Ms. Howson was executive vice president of business development at Lexicon Pharmaceuticals where she led the company’s partnering and licensing efforts. From 2001 to 2007, Ms. Howson was senior vice president corporate and business development at Bristol Myers Squibb, overseeing mergers and acquisitions, licensing and research collaborations. During 2000 and 2001, Ms. Howson served as a business development and strategy consultant to various biotechnology companies in the United States and in Europe. Ms. Howson was also a senior vice president and director of business development at SmithKline Beecham from 1991 to 2000, where she also managed SR One, SmithKline Beecham’s $100 million venture capital fund.
 
Ms. Howson currently serves on the board of directors of OXiGENE, Inc., a clinical-stage biopharmaceutical company developing therapeutics to treat cancer and eye diseases, and S*BIO Pte Ltd., which is focused on the discovery and clinical development of novel, targeted small molecule drugs for the treatment of cancer.  She is also a member of the Scientific Advisory Board of SAI Advantium Pharma Ltd., a drug discovery, development and manufacturing company.  She previously served as a director of Ariad Pharmaceuticals, SkyePharma, NPS Pharmaceuticals and Targacept.  Ms. Howson holds an M.B.A from Columbia University, an M.S. from City College of New York and a B.S. in Chemical Engineering from the Technion in Israel.
 
Ms. Howson brings strong business development, licensing and transactional guidance to our board of directors from her varied experiences at pharmaceutical companies and with venture capital.  The board believes with her background, Ms. Howson will provide important insights into licensing transactions, financing options and strategic collaborations for Idenix.
 
2010
 
 
The board of directors believes that approval of the election of each nominee director named above is in our best interests and in the best interests of our stockholders and therefore recommends a vote “FOR” this proposal.

 
8

 

DIRECTOR COMPENSATION

We compensate our non-employee directors, other than directors who are employees of Novartis, with a combination of cash and equity. Mr. Pelzer, Dr. Projan and Mr. Rosenberg, our three directors who are also employees of Novartis, do not receive any remuneration for their services as directors. We also do not provide additional remuneration to Dr. Sommadossi, an officer of Idenix, for his service as a director.

The following table describes our compensation practices for non-employee directors, other than the directors affiliated with Novartis, during the fiscal year ended December 31, 2009, or fiscal 2009.
 
               
Meeting Fees
   
Stock Options to Purchase
 
         
Cash
   
(Per Meeting
   
Common Stock(1)
 
   
Year
   
Retainer
   
Attended)
   
Initial
   
Annual
 
                                         
Board Member
   
2009
   
$
30,000
   
$
2,000
     
15,000
(2)
   
20,000
(3)
Lead Director
   
2009
     
10,000
     
     
     
 
Nominating and Corporate Governance Committee Chair
   
2009
     
5,000
     
1,000
     
     
 
Audit Committee Chair
   
2009
     
15,000
     
1,000
     
     
 
Compensation Committee Chair
   
2009
     
  10,000
     
 1,000
     
   —
     
   —
 
Committee Members (other than chair)
   
2009
     
     
1,000
     
     
 

(1)
The exercise price of these stock options is equal to the average of the open and close price of our common stock as reported on the NASDAQ Global Market on the date of grant. Subject to certain exceptions, each stock option terminates on the earlier of ten years from the date of grant or 180 days after the optionee ceases to serve as a director.

(2)
Each non-employee director is entitled to receive an award of stock options upon his or her election or appointment to our board of directors. The initial stock option grant vests in 24 equal monthly installments beginning one month from the date of grant.

(3)
Each non-employee director is entitled to receive at each year’s annual meeting after which he or she continues to serve as a director, an additional stock option grant of 20,000 shares. The number of stock options to be awarded to new non-employee directors who are appointed to our board of directors at times other than immediately after the annual meeting of stockholders is pro rated for the period of service between date of appointment and the next annual meeting. The annual option grant vests in 12 equal monthly installments beginning one month from the date of grant.
 
In addition, members of our board of directors, other than directors affiliated with Novartis, are reimbursed for reasonable expenses incurred in connection with attendance at meetings of our board of directors and its committees and related activities in accordance with Idenix policy.

Director Compensation for Fiscal 2009
 
   
Fees Earned or Paid
   
Stock Option
Awards
   
Total
 
Name
 
in Cash ($)
   
($)(1)(2)
   
($)
 
                         
Charles W. Cramb(3)
 
$
78,000
   
$
42,340
   
$
120,340
 
Wayne T. Hockmeyer(4)
   
65,000
     
42,340
     
107,340
 
Thomas R. Hodgson(5)
   
70,000
     
42,340
     
112,340
 
Denise Pollard-Knight(6)
   
60,000
     
42,340
     
102,340
 
Pamela Thomas-Graham(7)
   
60,000
     
42,340
     
102,340
 
Robert Pelzer(8)
   
     
     
 
Steven Projan(9)
   
     
     
 
Anthony Rosenberg(10)
   
     
     
 
Emmanuel Puginier (11)
   
     
     
 

 
9

 

(1)
The amounts in the Stock Option Awards column reflect the grant date fair value of stock option awards granted during fiscal 2009 under our stock incentive plans, in accordance with Financial Accounting Standards Codification Topic 718, Compensation-Stock Compensation, or FASB ASC Topic 718. There can be no assurance that FASB ASC Topic 718 amounts will reflect actual amounts realized. Refer to Note 10, “Equity Incentive Plans and Share-Based Compensation”, in the Notes to Consolidated Financial Statements included in the Annual Report on Form 10-K for fiscal 2009 filed with the Securities and Exchange Commission, or SEC, on March 9, 2010 for the relevant assumptions used to determine the valuation of our option awards.

(2)
The number of shares underlying stock options granted to our non-employee directors in fiscal 2009 and the grant date fair value of such stock options as determined in accordance with FASB ASC Topic 718 are:

         
Number of Shares
   
Grant Date Fair
 
         
Underlying Stock
   
Value of Stock Option
 
Director
 
Grant Date
   
Option Grants in 2009
   
Grants in 2009 ($)
 
Mr. Cramb
 
6/2/2009
      20,000       42,340  
Dr. Hockmeyer
 
6/2/2009
      20,000       42,340  
Mr. Hodgson
 
6/2/2009
      20,000       42,340  
Dr. Pollard-Knight
 
6/2/2009
      20,000       42,340  
Ms. Thomas-Graham
 
6/2/2009
      20,000       42,340  
Mr. Pelzer
    -       -       -  
Dr. Projan
    -       -       -  
Mr. Rosenberg
    -       -       -  
Dr. Puginier
    -       -       -  

(3)
At December 31, 2009, Mr. Cramb held stock options to purchase 140,000 shares of our common stock.

(4)
At December 31, 2009, Dr. Hockmeyer held stock options to purchase 100,000 shares of our common stock.

(5)
At December 31, 2009, Mr. Hodgson held stock options to purchase 100,000 shares of our common stock.

(6)
At December 31, 2009, Dr. Pollard-Knight held stock options to purchase 80,000 shares of our common stock.

(7)
At December 31, 2009, Ms. Thomas-Graham held stock options to purchase 115,000 shares of our common stock.  Ms. Thomas-Graham ceased serving as a member of the board on January 11, 2010. Under our 2005 Stock Incentive Plan, Ms. Thomas-Graham has 180 days from the date she ceased serving as a member of the board to exercise her then vested options. None of Ms. Thomas-Graham’s options may vest subsequent to January 11, 2010 .

(8)
Mr. Pelzer was nominated by Novartis as one of its three designees to our board. Mr. Pelzer does not receive compensation for serving on our board due to his affiliation with Novartis.

(9)
Dr. Projan joined our board of directors in February 2009. He was nominated by Novartis as one of its three designees to our board. Dr. Projan does not receive compensation for serving on our board due to his affiliation with Novartis.

(10)
Mr. Rosenberg joined our board of directors in June 2009. He was nominated by Novartis as one of its three designees to our board. Mr. Rosenberg does not receive compensation for serving on our board due to his affiliation with Novartis.

(11)
Dr. Puginier ceased serving as a member of the board in February 2009 upon Novartis’ nomination of Dr. Projan. Dr. Puginier did not receive compensation for serving on our board due to his affiliation with Novartis.

 
10

 

CORPORATE GOVERNANCE

Our board of directors strongly believes that good corporate governance policies and practices are important to ensure that Idenix is managed for the overall long-term benefit of our stockholders. We routinely review and update our corporate governance policies and practices that we believe will promote a high level of performance from our board of directors, officers and employees. This section describes key corporate governance guidelines and practices that our board has adopted. Complete copies of our Corporate Governance Guidelines, committee charters and Policy on Business Conduct and Ethics are available on our website at www.idenix.com under the caption “Investor Center — Our Leadership & Governance — Board of Directors, Committee Composition and Charters”. Alternatively, you can request a copy of any of these documents by writing to Secretary, Idenix Pharmaceuticals, Inc., 60 Hampshire Street, Cambridge, Massachusetts 02139.

Corporate Governance Guidelines

Our board has adopted Corporate Governance Guidelines to assist the board in the exercise of its duties and responsibilities and to serve the best interests of Idenix and our stockholders. These guidelines provide a framework for the conduct of the board’s business and includes guidelines for, among other things, determining director independence, establishing criteria and qualifications of directors, conduct of meetings of the board and meetings of independent directors, access by the directors to management, independent consultants and professional advisors, and management evaluation and succession.

Director Independence

Relationship with Novartis.   Under the terms of the stockholders’ agreement, we have agreed to use our reasonable best efforts to nominate for election as a director at least two designees of Novartis for so long as Novartis and its affiliates own at least 35% of our voting stock and at least one designee of Novartis for so long as Novartis and its affiliates own at least 19.4% of our voting stock. In May  2009, we and Novartis entered into a waiver and consent in connection with our filing of a registration statement to register shares of our common stock with the SEC, pursuant to which we granted Novartis the right to designate an additional director to serve on our board of directors, including the right, for up to one year, to remove and replace such designee.  The waiver and consent is effective through December 31, 2010.

We have also agreed, for so long as one or more Novartis designees serve on our board of directors, to permit Novartis-designated directors to serve on our board committees unless such committee service is prohibited by applicable law, rule or regulation, in which case the Novartis designee is entitled to serve on our board committees as a non-voting observer.

Board of Directors.   Under applicable NASDAQ rules, a director will only qualify as an “independent director” if, in the opinion of our board of directors, that person does not have a relationship that would interfere with the exercise of independent judgment in carrying out the responsibilities of a director. Our board of directors has determined that none of the following five directors has a relationship that would interfere with the exercise of independent judgment in carrying out the responsibilities of a director, and that each of these directors is an “independent director” as defined in the NASDAQ rules: Charles W. Cramb, Wayne T. Hockmeyer, Thomas R. Hodgson, Tamar D. Howson and Denise Pollard-Knight.

Committees.   Our Audit Committee is composed entirely of independent directors as required by applicable SEC and NASDAQ rules, including Rule 10A-3 under the Securities Exchange Act of 1934, as amended, or the Exchange Act, with one Novartis-designated director, Anthony Rosenberg, who is not independent, serving as a non-voting observer. Our Compensation Committee is composed of independent directors with one Novartis-designated director, who is not independent, Robert Pelzer, serving as a non-voting observer.   Our Nominating and Corporate Governance Committee is composed of independent directors with one Novartis-designated director, who is not independent, Robert Pelzer, serving as a non-voting observer.
 
Meetings of Independent Directors

Our Corporate Governance Guidelines require that our independent directors regularly meet without management being present. On an as needed basis, the independent directors meet in executive session without management.

Director Attendance at Annual Meetings of Stockholders

Our Corporate Governance Guidelines provide that it is the responsibility of all of our directors to attend our annual meetings of stockholders. All directors serving on our board as of the 2009 annual meeting of stockholders attended that meeting.

Board of Directors

Our board of directors has responsibility for establishing broad corporate policies and reviewing our overall performance. Among the primary responsibilities of our board of directors is the oversight of the management of our company. Our directors remain informed of our business and management’s activities by reviewing documents provided to them before each meeting and by attending presentations made by our chief executive officer and other members of management. At each meeting of the board of directors, our directors are advised of actions taken by each board committee. Directors have access to our books, records and reports and independent advisors. Members of our management frequently interact with and are at all times available to our directors.

 
11

 

Our board of directors met ten times during fiscal 2009, three meetings of which were board meetings of our independent directors only. During fiscal 2009, each director, other than Dr. Puginier, attended at least 75% of the aggregate of the number of board meetings and the number of meetings held by all committees on which he or she then served.

Board Leadership Structure

At the current time, we do not separate the roles of chief executive officer and chairman of the board.  Jean-Pierre Sommadossi has served as the chairman of our board of directors since our inception and as our president and chief executive officer since November 2000. Our board of directors has determined that having the same individual hold both positions is in the best interests of Idenix and our stockholders and is consistent with good corporate governance for the following reasons:

 
·
Our chief executive officer is more familiar with our business and strategy than an independent, non-employee chairman would be and is thus better positioned to focus our board’s agenda on the key issues facing our company.
 
 
·
A single chairman and chief executive officer provides strong and consistent leadership for Idenix, without risking overlap or conflict of roles.
 
 
·
Oversight of our company is the responsibility of our board as a whole, and this responsibility can be properly discharged without an independent chairman.
 
 
·
Our lead director  provides similar benefits to those associated with an independent chairman.
 
In part because of our decision not to separate the two positions at this time, our board of directors has appointed Thomas R. Hodgson as lead director.  Mr. Hodgson is an independent director within the meaning of NASDAQ rules.  His duties as lead director include the following:
 
 
·
Chairing meetings of the independent directors in executive session.
 
 
·
Meeting with any director who is not adequately performing his or her duties as a member of our board or any committee.
 
 
·
Facilitating communications between other members of our board and our chairman and chief executive officer.
 
 
·
Working with our chairman and chief executive officer in the preparation of the agenda for each board meeting and in determining the need for special meetings of our board.
 
 
·
Reviewing and, if appropriate, recommending action to be taken with respect to written communications from stockholders submitted to our board.
 
 
·
Consulting with our chairman and chief executive officer on matters relating to corporate governance and board performance.
 
Our board believes that our current leadership structure is appropriate because our lead director is able to provide independent leadership and management oversight and our long-term chairman and chief executive officer is able to focus on both day-to-day business and strategy development.
 
Committees of Our Board of Directors

Our board of directors has the following three standing committees: Audit, Compensation and Nominating and Corporate Governance. Each of these committees acts under the terms of a written charter approved by our board of directors. Copies of the committees’ charters, as currently in effect, are posted on our website at www.idenix.com under the caption “Investor Center — Our Leadership & Governance — Board of Directors, Committee Composition and Charters”.

 
The Audit Committee assists the board of directors in its oversight of the integrity of our financial statements, compliance with legal and regulatory requirements relating to finance and financial reporting matters and understanding of our accounting and financial reporting processes. The Audit Committee also assists the board of directors in overseeing and monitoring our compliance with the legal and regulatory requirements applicable to our business operations. Our Audit Committee has the sole authority and responsibility to select, evaluate, compensate and replace our independent registered public accounting firm. Our board of directors has determined that Charles W. Cramb, the chair of the Audit Committee, is a financial expert under applicable SEC rules. The Audit Committee met 10 times in fiscal 2009.

 
12

 

 
The Compensation Committee assists the board of directors with its overall responsibility relating to compensation and management development, recommends for approval by the board of directors the compensation of our chairman and chief executive officer and our non-employee directors, establishes annually the compensation of our other officers, effects the engagement of, and terms of employment agreements and arrangement with, and the termination of all our officers and administers our equity incentive plans. The Compensation Committee met four times in fiscal 2009. The process and procedures followed by our Compensation Committee in considering and determining executive and director compensation are described below under the heading “Compensation Discussion and Analysis”.
 
 
 
The Nominating and Corporate Governance Committee assists in developing and recommending to our board of directors sound corporate governance principles and practices, identifying and recommending qualified individuals to become members of our board of directors and reviewing and making recommendations to our board of directors with respect to management succession planning. The Nominating and Corporate Governance Committee met two times and acted by written consent once in fiscal 2009.
 
While each committee has its own charter and designated responsibilities, the committees act on behalf of the entire board of directors. The committees regularly report on their activities to the entire board of directors, and all members of our board of directors are entitled to receive copies of each committee’s agendas and minutes.

None of the members of any committee of our board of directors is or has been an officer of Idenix. Mr. Pelzer, Dr. Projan and Mr. Rosenberg are employees of Novartis or its affiliates. The current members of the committees of our board of directors are set forth in the following table:
 
       
Nominating and Corporate
Audit Committee(1)
 
Compensation Committee(2)
 
Governance Committee(1)(2)
         
Charles W. Cramb (Chair)
 
Wayne T. Hockmeyer (Chair)
 
Wayne T. Hockmeyer (Chair)
Thomas Hodgson
 
Charles W. Cramb
 
Denise Pollard-Knight
Denise Pollard-Knight
       
 


(1)
Mr. Rosenberg is a non-voting observer of the Audit Committee. Mr. Pelzer had served on the Audit Committee as a non-voting observer until Mr. Rosenberg joined the Audit Committee as an observer.

(2)
Mr. Pelzer is a non-voting observer of the Compensation Committee and the Nominating and Corporate Governance Committee.
 
Information About Our Nominating Process

The Nominating and Corporate Governance Committee is responsible for identifying and evaluating individuals to become members of our board of directors, including the review of candidates recommended by our stockholders, and recommending such qualified individuals to our board of directors.

The process followed by the Nominating and Corporate Governance Committee to identify, evaluate and review candidates includes requests to members of our board of directors and others for recommendations, meeting from time to time to evaluate biographical information and background material relating to potential candidates, an assessment of such candidates’ qualifications vis-à-vis our director qualification standards described below, and interviews of selected candidates by members of the Nominating and Corporate Governance Committee and the board of directors. In addition, the Nominating and Corporate Governance Committee may retain the services of an executive search firm to help identify and evaluate potential director candidates.

 
13

 

Stockholders may recommend to the Nominating and Corporate Governance Committee individuals for consideration as potential director nominees by submitting on a timely basis the name and background of the candidate to the Nominating and Corporate Governance Committee, c/o Secretary, Idenix Pharmaceuticals, Inc., 60 Hampshire Street, Cambridge, Massachusetts 02139. The Nominating and Corporate Governance Committee will consider a recommendation if appropriate biographical information and background material is provided. In addition to the biographical and background information, the stockholder making such recommendation must include a statement as to whether the stockholder or the group of stockholders making the recommendation has beneficially owned more than 5% of our common stock for at least a year as of the date such recommendation is made. Assuming that appropriate biographical and background material is timely provided for candidates recommended by stockholders, the Nominating and Corporate Governance Committee will evaluate those candidates by following substantially the same process, and applying substantially the same criteria, as for candidates submitted by members of our board of directors or by other persons. If our board of directors determines to nominate a stockholder recommended candidate, such nominee’s name will be included in our proxy statement and our proxy card for the stockholder meeting at which such nominee’s election is recommended.

Our stockholders also have the right to nominate director candidates themselves, without any prior review or recommendation by the Nominating and Corporate Governance Committee or the board of directors, by following the procedures set forth under “Stockholder Proposals for the 2011 Annual Meeting.” Director candidates nominated in accordance with the procedures set forth under the first paragraph of such section will be included in our proxy materials but may not be included in our proxy card for the next annual meeting.

At the annual meeting, stockholders will be asked to consider the election of the nine director nominees described in Proposal 1. Each of these nominees has been nominated for election by the Nominating and Corporate Governance Committee.

Director Qualification Standards

Directors should possess the highest personal and professional ethics and integrity, understand and be aligned with our core values, and be committed to representing the long-term interests of our stockholders. Directors must also be inquisitive, objective and have practical wisdom and mature judgment.

Our corporate governance guidelines specify that the value of diversity on the board should be considered in the director identification and nomination process. We endeavor to have a diverse board of directors possessing strategic and policy-making experience and skills in business, healthcare, drug development, strategic collaborations, science and technology and  the international arena. In considering whether to recommend any candidate for inclusion in our board of director’s slate of recommended director nominees, including candidates recommended by stockholders, the Nominating and Corporate Governance Committee will apply the criteria set forth in the charter of the Nominating and Corporate Governance Committee. These criteria include the candidate’s integrity, business acumen, age, experience, diligence, conflicts of interest and the ability to act in the interests of all of our stockholders. The Nominating and Corporate Governance Committee does not assign specific weights to particular criteria and no particular criterion is necessarily applicable to all prospective nominees. Our board of directors believes that the backgrounds and qualifications of our directors, considered as a group, should provide diversity and a significant composite mix of experience, knowledge and abilities that will allow our board of directors to fulfill its responsibilities. Nominees are not discriminated against on the basis of race, religion, national origin, sexual orientation, disability or any other basis proscribed by law.

Directors must be willing to devote sufficient time to carrying out their duties and responsibilities effectively, and should be committed to serve on our board of directors for an extended period of time. Our board of directors does not believe that arbitrary term limits on directors’ service are appropriate since such term limits could result in the loss of directors who have developed insights into Idenix and our business and operations. Our board of directors annually engages in a self-evaluation process and a review of the requisite skills and criteria comprised by our board of directors and those to be sought in nominees for directors.
 
We require any director who reaches the age of 70 while serving as a director to retire from our board of directors effective at the end of his or her then current term.

At the annual meeting, stockholders will be asked for the first time to consider the election of Anthony Rosenberg and Tamar D. Howson as directors.  In June 2009, Novartis nominated Mr. Rosenberg as one of its three designees to our board. Mr. Pelzer and Dr. Projan are Novartis’ other designees to our board.    Ms. Howson was elected as a director in March 2010.

Communicating with the Board of Directors

We have established an Integrity Hotline for the confidential, anonymous submission by our directors, officers and employees of concerns regarding violations or suspected violations of our Policy on Business Conduct and Ethics, including matters relating to accounting and auditing matters. In addition, the Audit Committee has established procedures for the receipt, retention and treatment of communications received by us, our board of directors and the Audit Committee regarding accounting, internal controls or auditing matters.

 
14

 

Written communications from our stockholders and employees may be sent to: Idenix Pharmaceuticals, Inc., Audit Committee Chair, 60 Hampshire Street, Cambridge, Massachusetts 02139.
 
Stockholders who wish to send other communications to our board of directors should address such communications to Board of Directors, c/o Secretary, Idenix Pharmaceuticals, Inc., 60 Hampshire Street, Cambridge, Massachusetts 02139.
 
Our board of directors will give attention to written communications that are submitted by our stockholders and other interested parties. In general, communications relating to corporate governance and corporate strategy are more likely to be reviewed by our board than communications relating to ordinary business affairs, personal grievances and matters as to which we receive repetitive or duplicative communications. Absent unusual circumstances or as contemplated by committee charters and subject to any required assistance or advice from our counsel, the chair of the Nominating and Corporate Governance Committee is primarily responsible for monitoring communications from our stockholders and other interested parties and for providing copies or summaries to the other directors as he or she considers appropriate.
 
Policy on Business Conduct and Ethics
 
Our board of directors is committed to legal and ethical conduct in fulfilling its responsibilities. We expect all of our directors, officers and employees to act ethically, legally and with integrity and in compliance with our Policy on Business Conduct and Ethics as well as our other policies and standards of conduct. Our Policy on Business Conduct and Ethics includes the code of ethics that applies to our principal executive officer, principal financial officer, principal accounting officer and persons performing similar functions. Our Policy on Business Conduct and Ethics is posted on our website at www.idenix.com under the caption “Investor Center — Our Leadership & Governance — Idenix Policy on Business Conduct and Ethics” and we intend to post on our website all disclosures that are required by law or NASDAQ listing standards concerning any amendments to, or waivers from, any provision of our policy. No waivers from any provision of our policy have been granted.

Oversight of Risk

We face a number of risks in our business, including risks related to pre-clinical and clinical research and development, regulatory reviews, approvals and oversight, intellectual property filings, prosecution, maintenance and challenges, the establishment and maintenance of strategic alliances, competition, the ability to access additional funding for our business, as well as other risks. Our management is responsible for the day-to-day management of the risks that we face, while our board of directors, as a whole and through its committees, has responsibility for the oversight of risk management.  Our board and its committees fulfill this duty by discussing with management the policies and practices utilized by management in assessing and managing risks and providing input on those policies and practices.
 
Our corporate governance guidelines specify that our directors have an obligation to become and remain informed about the risks and problems that affect the company’s business and prospects. In general, our board oversees risk management activities relating to business strategy, acquisitions, capital allocation, organizational structure and certain operational risks. Our Audit Committee has the responsibility to review with management the company’s (i) system of internal controls and policies relating to the assessment of risk; (ii) policies with respect to risk assessment, risk management, the company’s major financial and operational risk exposures, and (iii)  and the steps that management has taken to monitor and control such exposures, including a review of the company’s insurance program.  The Audit Committee also has the responsibility to oversee the company’s compliance programs and monitor its performance by periodically reviewing significant compliance risk areas related to the company’s business and the steps management has taken to monitor, control and report such compliance risk exposures. Our Compensation Committee oversees risk management activities relating to our compensation policies and practices. Finally, our Nominating and Corporate Governance Committee oversees risk management activities relating to board composition and management succession planning.  Each committee reports to the full board on a regular basis, including reports with respect to the committee’s risk oversight activities as appropriate.  In addition, since risk issues often overlap, committees from time to time request that that the full board discuss particular risks.
SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
 
Beneficial Ownership Table
 
The following table sets forth information regarding the beneficial ownership of our common stock as of April 1, 2010 by:

 
each person or group known by us to beneficially own more than 5% of our outstanding common stock;

 
each of our directors, including our chief executive officer;


 
each of the other executive officers named in the Summary Compensation Table under the heading “Executive Compensation” below; and

 
all of our current executive officers and directors as a group.
 
Unless otherwise indicated, to our knowledge, each of the persons named in this table has sole voting and investment power with respect to the shares indicated as beneficially owned, subject to community property laws where applicable.

           
Shares of
       
   
Shares of
     
Common Stock
   
Percentage of
 
   
Common Stock
     
Issuable Under
   
Common Stock
 
Name and Address of Beneficial Owner (1)
 
Beneficially Owned (2)
     
Stock Options (2)
   
Outstanding (3)
 
                     
5% Stockholders
                   
Novartis AG
    31,322,836 (4)       -       47 %
MPM Capital L.P.
    3,321,534 (5)       -       5.0 %
Directors
                         
Jean-Pierre Sommadossi
    2,219,754 (6)       987,506       4.8 %
Charles W. Cramb
    7,200         138,333       *  
Wayne T. Hockmeyer
    41,708         98,333       *  
Thomas R. Hodgson
    92,324         98,333       *  
Robert E. Pelzer (7)
    -         -       -  
Denise Pollard-Knight
    -         78,333       *  
Steven Projan (8)
    -         -       -  
Tamar D. Howson
    -         5,208          
Anthony Rosenberg (9)
    -         -       *  
Other Executive Officers
                         
Douglas Mayers
    30,000 (10)       174,586       *  
Ronald Renaud, Jr.
    15,000         286,252       *  
David Standring
    67,375 (11)       164,688       *  
John Weidenbruch
    35,000         177,604       *  
All current directors and executive officers as a group (13 persons)
    2,508,361         2,209,176       6.9 %
 

*             Less than 1% of the shares of total common stock outstanding as of April 1, 2010.

(1)
The address of all of our executive officers and directors is in c/o Idenix Pharmaceuticals, Inc., 60 Hampshire Street, Cambridge, Massachusetts 02139. The address of Novartis AG is Lichtstrasse 35 CH-4002 Basel, Switzerland. The address of MPM Capital L.P. is 200 Clarendon Street, Boston, Massachusetts 02116.

(2)
Beneficial ownership is determined in accordance with the rules of the SEC and includes voting or investment power with respect to shares of our common stock. Shares of our common stock issuable under stock options that are exercisable within 60 days after April 1, 2010 are deemed outstanding and are included for computing the percentage ownership of the person holding the options but are not deemed outstanding for computing the percentage ownership of any other person.

(3)
On April 1, 2010, there were 66,373,742 shares of our common stock outstanding.

(4)
Consists of 31,322,836 shares held by Novartis Pharma AG, a direct, wholly owned subsidiary of Novartis AG. This information is based solely on information set forth in a Schedule 13D/A filed on November 2, 2005 jointly by Novartis AG and Novartis Pharma AG and subsequent Forms 4 filed on April 4, 2006, June 8, 2006, May 30, 2008, September 3, 2008, November 25, 2008, February 23, 2009, May 29, 2009, August 24, 2009 and February 26, 2010.

 
16

 

(5)
Consists of 2,949,488 shares held by BB BioVentures L.P., or BB BioVentures, 256,519 shares held by MPM Bioventures Parallel Fund L.P., or Parallel Fund, 37,299 shares held by MPM Asset Management Investors 1998 LLC, or Investors Fund, and 78,228 shares held by MPM Asset Management LLC, or AM LLC. BB BioVentures is under common control with Parallel Fund, Investors Fund and AM LLC. This information is based solely on information set forth in a Schedule 13G/A filed by such entities on February 11, 2010.

(6)
Includes 161,185 shares held by the Jean-Pierre Sommadossi 1998 Irrevocable Trust.

(7)
Mr. Pelzer serves as president and chief executive officer of Novartis Corporation, an affiliate of Novartis, and does not have sole or shared voting or dispositive power over shares held by Novartis.

(8)
Dr. Projan serves as vice president, global head of infectious diseases for Novartis Institute for Biomedical Research, Inc., an affiliate of Novartis, and does not have sole or shared voting or dispositive power over shares held by Novartis.

(9)
Mr. Rosenberg serves as global head of business development and licensing of Novartis and does not have sole or shared voting or dispositive power over shares held by Novartis.

(10)
Includes of 30,000 shares held by Dr. Mayers’ spouse.

(11)
Includes 200 shares held by Dr. Standring’s spouse.


The following table sets forth information relating to the individuals who serve as executive officers as of April 1, 2010:

  Name
 
Age
 
Position
         
Jean-Pierre Sommadossi, Ph.D. 
 
54
 
President and Chief Executive Officer and Chairman of the Board of Directors
Paul J. Fanning
 
52
 
Senior Vice President, Human Resources
Douglas Mayers, M.D. 
 
56
 
Executive Vice President and Chief Medical Officer
Ronald C. Renaud, Jr. 
 
41
 
Chief Financial Officer and Treasurer
David N. Standring, Ph.D. 
 
59
 
Executive Vice President, Biology
John Weidenbruch
  
49
  
Executive Vice President, General Counsel and Secretary
 
Jean-Pierre Sommadossi, Ph.D. is the principal founder of Idenix and has served as the chairman of our board of directors since our inception in 1998 and as our president and chief executive officer since November 2000. During the period from November 1999 to November 2000, Dr. Sommadossi served as our executive president and chief scientific officer. Prior to taking a sabbatical and then unpaid leave from November 1999 to November 2002, Dr. Sommadossi served as a professor of pharmacology, toxicology and clinical pharmacology and associate director of both the Center for AIDS Research and the Liver Center, University of Alabama at Birmingham School of Medicine from June 1992 to November 2000. From 1996 to 1999, Dr. Sommadossi served on the Research Agenda Committee of the AIDS Clinical Trial Group. Dr. Sommadossi holds a Pharm.D. and Ph.D. in Pharmacology from the University of Marseilles in France.
 
Paul J. Fanning has served as our senior vice president, human resources since December 2007 and as our vice president, human resources from March 2004 to December 2007. Prior to joining Idenix, Mr. Fanning was employed by The Foxboro Company and its affiliates from 1984 to 2004, most recently as vice president, human resources at Invensys Process Systems from 2000 to 2004. Mr. Fanning holds an M.B.A. from Babson College and a B.S. from the University of Massachusetts.
 
Douglas Mayers, M.D. has served as our executive vice president and chief medical officer since January 2007. Prior to joining Idenix, from May 2001 until January 2007, Dr. Mayers was with Boehringer Ingelheim Pharmaceuticals, Inc., (Boehringer Ingelheim) where he served as vice president, therapeutic area of virology and was responsible for the strategic coordination of all HIV and hepatitis clinical trials in phases I through IV. Prior to joining Boehringer Ingelheim, Dr. Mayers conducted clinical trials in HIV research during his seventeen years in the United States Navy and his subsequent three years as the head of infectious diseases with Henry Ford Hospital. Dr. Mayers completed his M.D. at the University of Pennsylvania.
 
Ronald C. Renaud, Jr. has served as our chief financial officer and treasurer since June 2007. Prior to joining Idenix, Mr. Renaud served as senior vice president, chief financial officer and treasurer of Keryx Biopharmaceuticals, Inc. (Keryx) from February 2006 to May 2007. Prior to joining Keryx, Mr. Renaud was a senior research analyst and global sector coordinator for JP Morgan Securities from May 2004 until February 2006, where he was responsible for the biotechnology equity research effort, covering all ranges of capitalized biotechnology companies. From 2001 to May 2004, Mr. Renaud held managing director posts at Charles Schwab & Co., SoundView Capital and Bear Stearns & Co., Inc., where he covered companies in the biotechnology and life sciences sectors. Mr. Renaud holds an M.B.A. from the Marshall School of Business at the University of Southern California and a B.A. from St. Anselm College.

 
17

 

David N. Standring, Ph.D. has served as our executive vice president, biology since December 2007 and previously as senior vice president, biology from March 2006 to December 2007 and previously served as vice president, biology from March 2002 to March 2006 and as our executive director of biology from September 2000 to March 2002. Prior to joining Idenix, from February 1998 to July 2000, Dr. Standring served as research fellow and then as associate director, virology department at Schering-Plough Research Institute, a division of Schering Plough Corporation, a pharmaceutical company. From November 1994 to January 1998, Dr. Standring served as group leader, hepatitis, virology department at Bristol-Myers Squibb Research Institute. From 1984 to 1994, Dr. Standring was on the faculty of the University of California at San Francisco. Dr. Standring holds a B.A. from St. John’s College, Oxford University and a Ph.D. in Bioorganic Chemistry from Harvard University.
 
John Weidenbruch has served as our executive vice president and general counsel since September 2006. Prior to joining Idenix, Mr. Weidenbruch served as vice president and general counsel at Abraxis BioScience Inc. (Abraxis) from October 2005 until September 2006. Prior to joining Abraxis, Mr. Weidenbruch worked at Amgen Inc. from January 1995 until October 2005 where he held positions of increasing responsibility including senior director of law operations and senior associate general counsel of global commercial operations. Mr. Weidenbruch holds a B.A. from Loyola College in Baltimore, Maryland and a J.D. from Georgetown University Law Center in Washington, D.C.
 
Each of our executive officers is elected or appointed by, and serves at the discretion of, the board of directors. In addition, until such time as Novartis and its affiliates own less than 40% of our voting stock, Novartis’ consent is required for the selection and appointment of our chief financial officer. If in Novartis’ reasonable judgment our chief financial officer is not satisfactorily performing his duties, we are required to terminate the employment of our chief financial officer. Each of our executive officers devotes his or her full time to our affairs.
 
Executive Summary

We have designed our executive compensation plan to support our business goals and promote the long term growth of the company.  Specifically, our compensation plan is designed to promote the achievement of key strategic and financial performance measures by linking executives’ short- and long-term cash and equity incentives to the achievement of measurable corporate and individual performance goals.

Total compensation of each executive officer varies with overall attainment of corporate objectives, as well as the performance of individual goals and objectives.  The total compensation for each of our executive officers is benchmarked against the total compensation of executive officers in comparable positions at a peer group of companies of similar size and market capitalization in the biotechnology sector, with a goal of compensating our executives appropriately and competitively.  A substantial portion of total compensation for our executive officers is tied to key corporate strategies and operational goals such as drug discovery initiatives, clinical trial progress and other operational and financial measures.

We provide a portion of our executive compensation in the form of stock options that vest and become exercisable over time, which we believe helps to retain our executives and to align their interests with those of our shareholders by allowing our executives  to participate in the longer term success of Idenix.  Our executive compensation program is structured to reflect the performance of our company overall by linking pay both to individual performance and to the achievement of pre-determined corporate objectives and goals. We believe that executive compensation should help to attract, retain and motivate those executives we depend on for our current and future success.

Overview of Our Philosophy and Procedures for Determining Executive Compensation

The Compensation Committee of our board of directors has primary responsibility to assist the board in designing, implementing and maintaining compensation programs for our executive officers, including the oversight of the administration of our stock option plans. The responsibilities of the Compensation Committee, which are set forth in detail in the Compensation Committee charter and which can be found on our website at www.idenix.com under the caption “Investor Center — Our Leadership & Governance — Board of Directors, Committee Composition and Charters”, include:
 
 
·
recommending to the board of directors the compensation payable to non-employee directors;
 
 
·
determining the type and level of compensation for executive officers;
 
 
·
recommending to the board of directors the type and level of compensation for the chief executive officer; and
 
 
·
oversight of the administration of our stock option plan.
 
 
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The Compensation Committee seeks to ensure that the executive compensation programs contain an appropriate amount of compensation that is at risk and subject to the achievement of critical business objectives.
 
To help evaluate the appropriate levels of compensation with respect to each component of our compensation program, the Compensation Committee annually reviews the compensation level of our named executive officers and other key executives against the compensation levels of comparable positions of a peer group of companies.  The Compensation Committee has the authority to retain compensation consultants and other outside advisors to assist in the evaluation of executive officer compensation. In recent years, including 2009, the Compensation Committee retained Towers Watson (formerly known as Towers Perrin), an independent executive compensation consulting firm, to provide assistance in evaluating and developing our executive compensation program.  Towers Watson provides the Compensation Committee with relevant market data regarding executive compensation.  The Compensation Committee uses this market data as a guide against which the Compensation Committee evaluates the compensation of each of the executive officers, including the named executive officers, in light of the executive’s scope of responsibility and expertise. Towers Watson provides consulting activities on behalf of the Compensation Committee and does not provide consulting or additional services for Idenix management.
 
Towers Watson generally provides the following:

 
·
compensation survey data to the Compensation Committee for purposes of benchmarking or comparing each compensation component within our executive compensation program, namely base salary, cash incentive programs, equity programs and benefits, to a group of other publicly traded companies engaged in the discovery and development of drug products. The peer group is based on the similarity of their revenue size and market capitalization;
 
 
·
assistance to interpret various sets of compensation data;
 
 
·
its own views on our compensation policies in general, compensation packages for each of our executives and the competitiveness and effectiveness of our executive officer compensation levels; and
 
 
·
assistance in the selection of our peer group companies.
 
In gathering competitive market compensation data, Towers Watson generally utilizes two primary sources:
 
 
·
published compensation surveys for biotechnology and pharmaceutical companies; and
 
 
·
proxy information of selected peer organizations.
 
In fiscal 2009, Towers Watson utilized the Radford Global Life Sciences survey and comparable executive compensation information published in publicly available proxy statements from the peer group organizations set forth below to develop the competitive benchmark analysis.  In addition, Towers Watson considered the overall economic environment and trends within the biopharmaceutical industry when making their observations and recommendations.  A representative from Towers Watson presented its findings and observations prior to the Compensation Committee making any determination or recommendation regarding the compensation of the executive officers.

In fiscal 2009, the Compensation Committee established total compensation targets for the executive officers using the Radford survey and the proxy information of a peer group comprised of 15 companies.  The Compensation Committee reviews and approves the list of peer companies each year.  Our current peer group consists of the following:

 
·
Adolor Corporation,
 
·
Arena Pharmaceuticals Inc.,
 
·
ARIAD Pharmaceuticals Inc.,
 
·
Array BioPharma Inc.,
 
·
Cytokinetics Inc.,
 
·
Insight Corporation,
 
·
Inspire Pharmaceuticals Inc.,
 
·
InterMune Inc.,
 
·
Lexicon Pharmaceuticals Inc.,
 
·
Maxygen Inc.,
 
·
Neurocrine Biosciences Inc.,
 
·
Pharmasset Inc.,
 
·
Rigel Pharmaceuticals Inc.,
 
·
Theravance Inc., and
 
·
ZymoGenetics Inc.

 
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The Compensation Committee’s philosophy is to target our executive officers’ compensation at a competitive rate, generally between the 50 th and the 75 th percentiles for total annual compensation, using the Towers Watson benchmark data to provide analysis and specific information with respect to the peer group discussed above, as well as the Radford Global Life Sciences survey.  Benchmarking and aligning base salaries is critical to the compensation program since other elements of our compensation are affected by changes in base salary.  For example, payments under our annual cash performance incentive plan are targeted and paid out as a percentage of base salary.  Adjustments to the base salary in any year are made based on comparisons to the survey data noted above and evaluation of the executive’s level of responsibility and experience as well as company-wide performance.

Our executives are eligible to participate in our annual cash performance incentive plan, which is an annual variable cash pay plan offered to all our employees.  The payouts for executives are paid when pre-determined individual and corporate goals are met.

Our executives are also eligible to participate in long-term incentives through stock option grants, with the potential to benefit if shareholder value is increased as a result of increases in our stock price.

In addition to reviewing the compensation of the named executive officers against the comparative data developed by Towers Watson, the Compensation Committee also considers benchmarking data as well as recommendations from our chief executive officer regarding compensation for all other personnel holding the position of vice president or higher. With respect to our chief executive officer, the Compensation Committee recommends his target cash performance incentive and target equity amounts to our board for approval.   The Compensation Committee’s recommendation is based upon several factors, including the benchmarking of our chief executive officer’s compensation against comparative data prepared by Towers Watson and, as more fully discussed below, achievement of corporate goals and objectives for the upcoming year.

Lastly, the Compensation Committee reviews a comprehensive analysis of all elements of each named executive officer’s compensation, including any amounts payable under severance or change-in-control arrangements under post-employment scenarios.  This review also analyzes how changes in any element of compensation could impact other elements, particularly severance or change-in-control benefits, if applicable to the executive.  Such analysis has become a key component in the Compensation Committee’s review of executive compensation as the analysis allows the Compensation Committee to consider an executive’s overall compensation rather than only one or two specific components.

Review of Management’s Actual Performance Compared to Pre-Determined Goals
 
In the first quarter of each fiscal year, corporate and individual goals for the year are drafted by the chief executive officer and the executive officers.  These goals are weighted by relative importance to Idenix’s success.  The corporate goals are presented to the Compensation Committee, which actively engages in the process of setting and finalizing the objectives for review and recommendation to the full board of directors.  The corporate goals are finalized and approved by the board of directors.   The extent to which corporate and individual goals are achieved is used in determining annual cash incentive payments and is considered in determining equity awards for our executives.
 
Upon completion of the fiscal year, the chief executive officer evaluates the performance of each executive officer and assigns a proposed rating to such officer based upon his or her achievement of the corporate and individual goals.  The chief executive officer presents a summary recommendation to the Compensation Committee of the performance evaluations and ratings along with compensation recommendations for the executive officers.  The Compensation Committee determines an overall corporate rating based on performance against the corporate goals, as further described below, and decides whether to approve or adjust the recommendations for individual executives made by the chief executive officer.  In determining the actual success of the executive’s performance in any year, including fiscal 2009, the Compensation Committee considers the difficulty of attaining the corporate and individual objectives, whether there were any extenuating circumstances or factors that needed to be considered, and whether the stated objectives were met.

In addition, the Compensation Committee meets in executive session to discuss and review the compensation of the chief executive officer and his performance over the past year compared to the previously approved goals for the corresponding year and upon third party compensation benchmark data prepared by Towers Watson.  The Compensation Committee provides recommendations regarding compensation for the chief executive officer to our board of directors. Our board of directors reviews and approves any changes in our chief executive officer’s compensation by the end of the first quarter of the fiscal year.

No executive officer, including our chief executive officer, recommends or determines any element or component of his or her own pay package or total compensation amount.

 
20

 

In the first quarter of each fiscal year, the Compensation Committee evaluates the company’s actual performance for the prior year against the predetermined corporate objectives to establish an overall performance rating for the company as a whole.  This overall performance rating then determines the amount of funding for the total cash incentive pool for all employees, as discussed more fully below.  The Compensation Committee uses a rating scale of 1 to 3 to evaluate each corporate objective.  A rating above 2 is given for exceeding the targeted objective, a rating of 2 indicates the objective was achieved and a rating of below 2 indicates the objective was not fully achieved.   The Compensation Committee evaluates each objective, establishes a rating for each and then determines an overall corporate rating based on the weighting of the objectives and the extent to which they were achieved.  The determination of the corporate rating, while based primarily on the numerical rating for each objective and the relative weight assigned to each objective, also reflects a subjective analysis by the Compensation Committee.  A corporate rating of 2.0 typically results in the funding of 100% of the aggregate target cash incentive bonus pool.  A corporate rating of 2.0 will equate to meeting the target bonus at 100%, while a rating higher than 2.0 will typically equate to a payment greater than the target amount, and a rating below 2.0 will typically equate to a payment less than the target amount.  The overall corporate rating is then used to determine the individual cash incentive amounts for each executive officer.  Other than the Chief Executive Officer, a blending of individual and corporate goal attainment will determine actual bonus payout. The Chief Executive Officer’s bonus payout is based solely on the corporate rating.

2009 Corporate Objectives

For 2009, the following represents a summary of our five major corporate categories and goals, achievements and respective relative weightings:
 
 
1.
IDX184: a drug candidate for the treatment of hepatitis C virus, or HCV, which accounted for 25% of our overall corporate goals
 
Goal: Completing a three day proof-of-concept clinical study of IDX184.
 
Achievement: We successfully completed the proof-of-concept clinical study of IDX184.
 
Goal: Submitting a notice of the results of proof-of-concept clinical study pursuant to our development and commercialization agreement with Novartis under which Novartis has a right to license IDX184 and other drug candidates from us.

Achievement: Notice of the results of proof-of-concept clinical study was submitted to Novartis pursuant to our development and commercialization agreement with Novartis.

Goal: Initiating a Phase IIa 14-day triple combination study of IDX184 with standard of care.

Achievement: Triple combination study of IDX184 was initiated in 4Q 2009 .
 
 
2.
IDX375: an HCV non-nucleoside HCV polymerase program, which accounted for 20% of our overall corporate goals
 
Goal: Completing toxicology and pharmacology studies in order to allow for an investigational new drug application, or IND, with the United States Food & Drug Administration, or FDA, or clinical trial application, or CTA, with the appropriate regulatory agency outside the United States, to be filed with the appropriate regulatory agency for IDX375 .

Achievement: Toxicology and pharmacology studies were completed allowing for CTA filing in 4Q 2009.

Goal: Filing an IND, and/or CTA, with the appropriate regulatory agency, for IDX375.

Achievement: We filed in 4Q 2009 a CTA for IDX375, a non-nucleoside polymerase inhibitor for the treatment of HCV.

Goal: Completing single ascending dose study of IDX375 in healthy volunteers.

Achievement: Single ascending dose study in healthy volunteers was completed for IDX375 choline salt.

 
3.
IDX320: a protease inhibitor program, which accounted for 20% of our overall corporate goals
 
Goal: Completing toxicology and pharmacology studies in order to allow for an IND or CTA to be filed with the appropriate regulatory agency for IDX320.
 
Achievement: Completed IND enabling toxicology and pharmacology studies for IDX320 in 4Q 2009.
 
Goal: Filing an IND with the FDA and/or CTA with the appropriate regulatory authority, for IDX320.
 
Achievement: We filed in Q4 2009 a CTA for IDX320.

 
21

 

 
4.
Discovery: Our discovery program, pursuant to which we seek to identify and begin early stage research and development of potential clinical candidates, accounted for 20% of our overall corporate goals
 
Goal: Identifying a portfolio of potential clinical candidates from our early stage development programs, including nucleosides/nucleotides, polymerase inhibitors, protease inhibitors and NS5A inhibitors.

Achievement: A number of novel compounds have been identified in different classes including NS5A inhibitors and non-nucleoside polymerase inhibitors from a distinctly different active binding site than IDX375. We continue to assess the possibility of further development of these compounds through a process known as “lead optimization.”

 
5.
  General Operations: accounted for 15% of our overall corporate goals
 
Goal: Objectives relating to general operations of the company, including budget control, forecasting and financial reporting.
 
Achievement: All objectives were achieved in the budget and financial reporting area.
 
Goal: Raise sufficient funds to enable the company to operate beyond 2010.
 
Achievement: We raised $21 million and although less than anticipated, we managed our cash burn to enable the company to operate beyond 2010.     
 
Based on the above, the Compensation Committee determined that Idenix had attained an overall corporate rating of 2.14

Components of Our Executive Compensation Program
 
The primary elements of our executive compensation program are:
 
 
·
base salary;
 
 
·
annual cash performance incentive;
 
 
·
cash signing bonus;
 
 
·
stock option awards;
 
 
·
benefits and
 
 
·
severance and change-in-control payments.
 
We do not have a formal process for allocating compensation between long-term and short-term compensation or between cash and non-cash compensation, but, as discussed above, we do analyze peer group data and related third party information. The Compensation Committee, after reviewing information provided by Towers Watson, determines subjectively what it believes to be the appropriate level and mix of the various compensation components.
 
Base Salary
 
Base salary is used to recognize the experience, skills, knowledge and responsibilities required of all our employees, including our executives.  When establishing base salaries for 2009, the Compensation Committee considered the level of an individual’s responsibility and experience, and reviewed both comparable positions in the market and the market demand for such executive’s skill sets at the time of hire (as applicable).  Base salaries may be increased for merit reasons, based on the executive’s success in meeting or exceeding individual performance objectives as well as our combined success in meeting corporate goals, subject to minimum salary requirements set forth in applicable employment agreements.  Salaries for individual executive officers are compared to peer group companies based on the surveys and proxy statement information described above.  Base salaries may also be adjusted to maintain market competitiveness, as compared to our peers.

In the case of Jean-Pierre Sommadossi, our chief executive officer, Ronald Renaud, our chief financial officer and treasurer, Douglas Mayers, our executive vice president, clinical development, and chief medical officer, and John Weidenbruch, our executive vice president and general counsel, the minimum base salary is mandated by our written employment arrangements with those executives.  Merit increases generally take effect in February or March of each year.

 
22

 

During 2009, the Compensation Committee determined that in consideration of market conditions, none of our executive officers would receive an increase in base salary.  The annual base salaries remained at the same rate as established in 2008, as set forth below.
 
For 2010, our board of directors determined, following a recommendation by management, that our chief executive officer’s base salary would again not be increased.  The Compensation Committee also determined, following a recommendation by management, that the respective base salaries of our chief financial officer, chief medical officer and executive vice president and general counsel would not be increased from their current levels.  Management’s recommendation was based on the continued market volatility and information  provided by Towers Watson to the Compensation Committee.  The base salary of David Standring, our executive vice president of biology, was increased from $260,000 to $270,000 in recognition of the responsibilities he has assumed in the discovery area.
 
Named Executive Officer
 
Title
 
2009 Salary
   
2010 Salary
 
                 
Jean-Pierre Sommadossi
 
Chief Executive Officer
  $ 580,000     $ 580,000  
                     
Ronald Renaud
 
Chief Financial Officer and Treasurer
  $ 350,200     $ 350,200  
                     
Douglas Mayers
 
Executive Vice President, Clinical
Development, and Chief Medical Officer
  $ 330,000     $ 330,000  
                     
David Stranding
 
Executive Vice President, Biology
  $ 260,000     $ 270,000  
                     
John Weidenbruch
 
Executive Vice President and General Counsel
  $ 324,450     $ 324,450  

Annual Cash Performance Incentive
 
We have an annual cash performance incentive plan for our executives, as discussed above.  The annual cash performance incentive is intended to compensate for the direct contribution made by the executive to the achievement of company strategic, operational and financial goals through individual effort and achievement.  Amounts payable under the annual cash performance incentive plan are calculated as a percentage of the executive’s base salary.  A target annual incentive amount is established at the beginning of each year.  The plan allows for awards ranging from 0% to 200% of the cash target amount.  The actual cash performance incentive award is determined according to each named executive officer’s level of achievement against the corporate and individual objectives for all executives other than Dr. Sommadossi.   Due to the expectations uniquely associated with his position, Dr. Sommadossi’s cash incentive award is based solely on the achievement of corporate goals and objectives.  The other named executive officers’ respective cash incentive awards were based in part on the achievement of individual objectives as well as corporate objectives.
 
As noted above, the Compensation Committee set the overall corporate rating at 2.14 for 2009.  According to the compensation bonus plan approved by the Compensation Committee and the board of directors, the overall corporate rating determines the total funding of the cash incentive pool available for all employees, including the named executive officers.  Each named executive officer is given an overall rating, based upon the corporate performance rating discussed above and his or her level of achievement against his or her individual pre-determined objectives.  Under the plan, a corporate rating of 2.14 should typically result in the funding of 110% of the aggregate target cash incentive pool.  However, management recommended to the Compensation Committee that in light of the company’s current financial resources, the actual incentive funding payout be reduced to an aggregate of 100%.  The committee, while recognizing the importance of management’s recommendation, determined that the payouts should exceed target in several instances, as further described below.
 
Based on the Compensation Committee’s assessment of the overall corporate performance and Dr. Sommadossi’s contributions toward this performance, it was determined that Dr. Sommadossi would be awarded a cash performance incentive above his target.   Specifically, the Compensation Committee acknowledged as a significant accomplishment Dr. Sommadossi’s leadership in advancing multiple classes of HCV compounds from discovery through the IND stage and the speed at which the company was able to reach these milestones.
 
Mr. Renaud’s overall rating was weighted based on the achievement of the goals associated with the general and financial operations of the company, development of an HCV product valuation model and individual goals linked to infrastructure improvements.  Mr. Renaud received a cash performance incentive at target based on these accomplishments as well as his strategic role in working with our key business partners including both Novartis and GSK.
 
Dr. Mayers’ overall rating was weighted based on the achievement of goals associated with the clinical development of our compounds IDX184 and IDX375 and individual goals in support of other programs.  Dr. Mayers’ cash performance incentive was slightly below his target because not all clinical development goals pertaining to his department were fully realized within specified timeframes during 2009.

 
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Dr. Standring’s overall rating was weighted based on the achievement of goals associated with IDX184, IDX375, IDX320 and our discovery program, with an individual goal associated with the transfer of a screening operation within Idenix. Dr. Standring’s cash performance incentive was above target due to his contributions to the corporate goals and the transition of the screening operation with minimal disruption.
 
Mr. Weidenbruch’s overall rating was weighted based on both the achievement of corporate goals associated with general operations and his individual goals.  Mr. Weidenbruch’s cash performance incentive was above target due to his efforts achieving corporate goals relating to general operations, solidifying our position in the area of intellectual property and the completing restructuring activities in Europe.
 
The targeted cash performance incentive awards set in February 2009, along with actual amounts paid in 2010 for performance in 2009, for our named executive officers is set forth in the following table:
 
Named Executive
Officer 
 
Title
 
2009 Targeted Cash
Performance
Incentive As a
Percentage of Base
Salary
   
Actual
Performance
Incentive As a
Percentage of
Base Salary
for  2009
   
Actual Cash
Performance
Incentive Paid for
2009
 
                             
Jean-Pierre Sommadossi
 
Chief Executive Officer
    60 %     69 %  
$ 400,000
 
                             
Ronald Renaud
 
Chief Financial Officer and Treasurer
    50 %     50 %  
$ 175,000
 
                             
Douglas Mayers
 
Executive Vice President, Clinical Development, and Chief Medical Officer
    50 %     42 %  
$ 140,000
 
                             
David Standring
 
Executive Vice President, Biology
    35 %     40 %  
$ 105,000
 
                             
John Weidenbruch
 
Executive Vice President and General Counsel
    40 %     43 %   $ 140,000  
 
The incentive awards set forth in the table above were paid to the named executive officers in late February 2010.  Furthermore, in reviewing current bonus targets for the named executive officers compared to our peer group, the Compensation Committee determined that Dr. Standring’s bonus target should be increased to 40% of base salary for the fiscal year ending December 31, 2010.  The bonus targets for the other executive officers remain at the same level for 2010.
 
Cash Signing Bonuses
 
In certain circumstances, we provide cash signing bonuses in order to attract highly qualified talent. Whether a signing bonus is paid and the amount thereof, is determined on a case-by-case basis based on the specific circumstances surrounding the hiring of a new executive officer.  We will consider paying signing bonuses to compensate the executive for amounts forfeited when the executive leaves a previous employer, or to create additional incentive for executives to join our company in a position where there is high market demand.

 
24

 

Stock Options
 
Our stock option program is the primary vehicle for offering long-term incentives to our executives, although the Compensation Committee has the authority to award other forms of equity-based compensation under our stock incentive plan.  We believe that stock option grants provide our executives with a strong link to our long-term performance and create an ownership culture and help align the interests of our executives and shareholders.  In addition, the vesting feature of our stock option grants furthers our goal of executive retention because this feature provides an incentive to our executives to remain in our employ during the vesting period.  The Compensation Committee and the board closely oversee the annual “burn rate” or stock utilization rate under our stock option program to ensure that it is appropriate in proportion to the overall corporate stock option plan.  We use the term “burn rate” to mean, and burn rate is generally defined as, the total number of shares subject to all equity awards granted during the fiscal year divided by the total number of shares outstanding plus the shares available for grant under our stock incentive plans at the end of the fiscal year.  Our burn rate was 3.0% from fiscal year 2007 through the end of fiscal 2009, which is within the industry guidelines established by Risk Metrics, Inc., and is below the median of our peer group.
 
The annual target equity awards for named executive officers are set forth in such officer’s respective employment agreement, each of which have been filed as exhibits to our Annual Report on Form 10-K for the year ended December 31, 2009.  The Compensation Committee reviews these targets, and if necessary, makes any appropriate adjustments each year as part of the annual review process.  The executive officers are awarded stock options with an exercise price equal to the fair market value of Idenix common stock on the date of the grant.  For executive officers other than our chief executive officer, the Compensation Committee grants options that vest monthly over a four-year period.  The stock options awarded to our chief executive officer typically vest over a five-year period with 25% of the award vesting on the first anniversary of the date of the grant and the remaining 75% vesting on a monthly basis over the next four years.  Our chief executive officer has a longer vesting schedule for greater retention impact of the option grant.
 
Stock Option Grant Practices
 
Stock awards to our executives are typically granted annually in conjunction with the review of their individual performance.  This review takes place at the regularly scheduled meeting of the Compensation Committee held during the first quarter of the fiscal year. From time to time stock awards are made at other times during the year.  During this review, the chief executive officer provides stock option award and target recommendations for the executive officers to the Compensation Committee.  The Compensation Committee reviews the recommendations and is ultimately responsible for approval of all option grants and target amounts to executive officers, other than to our chief executive officer.    Stock option grants and target amounts regarding our chief executive officer are recommended by the Compensation Committee for approval by our board of directors.  In February 2009, the board of directors approved a stock option grant of 200,000 shares at an exercise price of $5.46 under our 1998 equity incentive plan to our chief executive officer.  After the stock option grant was approved, it was determined that the stock options could no longer be awarded under the 1998 plan and, accordingly this stock option award was not granted.  In March 2010, our board of directors reapproved a stock option grant of 200,000 shares at an exercise price of $5.46 under our 2005 equity incentive plan.  In an effort to address the vesting that would have occurred between February 2009 and the reapproval of this stock option grant in March 2010, our board of directors modified the vesting period for the March 2010 grant so that the intended vesting schedule would not be affected by the re-approval of the grant.
 
Determination of Stock Option Exercise Prices
 
Stock options are granted with an exercise price equal to the fair market value on the grant date, calculated as the average of the open and close prices of our common stock as reported on the NASDAQ Global Market on such date.  Idenix has not re-priced stock options or granted any options below fair market value on the grant date.
 
Initial New Hire Grant
 
Idenix provides an initial stock option award to all employees with regular employment status, which includes our executive officers.  The amount of the award is based upon similar grants to individuals holding comparable positions in peer group companies, based on survey data.  The amount of the initial stock option award is also reviewed in light of the employee’s base salary and other compensation to ensure that the employee’s total compensation is in line with our overall compensation philosophy.
 
Annual Stock Option Awards
 
Executive officers are eligible for an annual stock option grant which is also a key part of our overall compensation program.  As with the Compensation Committee’s determination of base salary and initial stock option awards, in considering annual stock option awards for our executives, the committee conducts a review of all components of the executive’s compensation to ensure that an executive’s total compensation is consistent with our overall philosophy and objectives.  Among other factors analyzed in determining an annual grant are the individual executive’s performance over the prior year, the company’s performance over the prior year and comparable market data.

 
25

 

Stock Option Grants for Fiscal 2009 and Target Grants for Fiscal 2010
 
In February 2010, the named executive officers received long-term incentive awards as part of the annual review process for 2009 performance.  No other long-term incentive awards were granted to the named executive officers in connection with their performance in 2009.  These long-term awards granted for fiscal 2009 were higher than target amounts for almost all of the named executive officers principally because the Compensation Committee considered an analysis prepared by Towers Watson that indicated that that the equity targets for our named executive officers were well below targeted market positions when compared to our peer group, as further discussed below.  The Compensation Committee recognized the need to retain and incentivize our executive management team in light of current market conditions. For our 2009 fiscal year long-term incentive compensation, the Compensation Committee authorized a grant of stock options, which was made on February 10, 2010, to the named executive officers, including our chief executive officer. Also on February 10, 2010, the board approved a stock option grant to our chief executive officer based on a recommendation of the Compensation Committee. Set forth in the table below are the stock option targets for fiscal 2009 for our named executive officers and the actual number of options granted to such named executive officers for fiscal 2009.

Our chief executive officer, Dr. Sommadossi, was granted 100,000 stock options greater than target for fiscal 2009 both in light of the analysis prepared by Towers Watson and in recognition of the achievement of corporate goals.
 
Mr. Renaud, our chief financial officer, was granted 20,000 stock options greater than target for fiscal 2009 both in light of the analysis prepared by Towers Watson and in recognition of the achievement of individual and corporate goals for fiscal 2009.
 
For fiscal 2009, our chief medical officer, Dr. Mayers, was granted an option award equal to his target for stock option awards in consideration of his level of achievement of individual and corporate goals for fiscal 2009 and to maintain market competiveness.
 
Dr. Standring, our executive vice president of biology, was granted 20,000 stock options greater than target for fiscal 2009 in recognition of the achievement of individual and corporate goals for 2009.
 
Mr. Weidenbruch, our general counsel, was granted 20,000 stock options greater than target for fiscal 2009 both in light of the analysis prepared by Towers Watson and in recognition of the achievement of individual and corporate goals for 2009.
 
The Compensation Committee (and the board, in the case of Dr. Sommadossi) determined that in light of market data, for the year ending December 31, 2010, the targeted shares underlying options be increased for the named executives set forth in the table below.
 
Named Executive
Officer 
 
Title
 
Targeted Shares
Underlying Stock
Options for fiscal
2009
   
Stock Options
Granted for
fiscal 2009
   
Targeted
Shares
Underlying
Stock Options
for fiscal 2010
 
                       
Jean-Pierre Sommadossi
 
Chief Executive Officer
    300,000       400,000       400,000  
Ronald Renaud
 
Chief Financial Officer and Treasurer
    80,000       100,000       110,000  
Douglas Mayers
 
Executive Vice President, Clinical Development, and Chief Medical Officer
    40,000       40,000       60,000  
                             
David Standring
 
Executive Vice President, Biology
    30,000       50,000       50,000  
John Weidenbruch
 
Executive Vice President and General Counsel
    80,000       100,000       90,000  

Grants of stock options are designed and administered so that they are not subject to the limits on the company’s ability to take federal income tax deductions for executive compensation over $1.0 million per year, imposed by Section 162(m) of the Internal Revenue Code of 1986, as amended.

Benefits

We maintain benefits that are provided to all employees, including health and dental insurance, life and disability insurance and a 401(k) plan. All eligible and participating employees receive a 401(k) match of twenty-five percent (25%) on pre-tax contributions, up to the first six percent (6%) of eligible compensation. Executive officers are eligible to participate in all of our employee benefit plans, in each case on the same basis as other employees.

 
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We also provide all employees, including executive officers with a flexible spending account plan and paid time off benefits including, vacation, sick time and holidays.   In addition, we provide the chief executive officer with company-paid life insurance, with a death benefit amount of $2.0 million and company-paid disability with an aggregate benefit amount of $2.0 million, either payable in a lump-sum or as an annuity.  We also provide, from time to time, payment or reimbursement of expenses in connection with the relocation of our executive officers, including amounts required to gross up these expenses for tax purposes.

The Compensation Committee analyzed the total compensation package for each executive to determine whether our current combination of compensation elements provided to our executives contains what are considered to be an appropriate mix of cash compensation, long term incentive and indirect compensation.  The Compensation Committee concluded that the total compensation mix is appropriately structured at the present time with a significant portion of the total compensation placed on the variable awards such as the annual incentive bonus and the long term component in the form of stock options while keeping a lower portion in the fixed area of benefits.  We believe that this mix emphasizes the performance aspect of the compensation framework and is consistent with the interests of our shareholders.  We do not offer or provide any additional perquisites to the chief executive officer or any other officer of the company.

Severance and Change-in-Control Payments
 
We have entered into employment agreements with each of our named executive officers providing for, among other things, severance and change-in-control benefits as described below. We have worked to design our severance and change-in-control arrangements to be competitive, and we periodically review  these arrangements relative to   current market trends.  We review the total compensation arrangements for each of our executives  to determine whether the potential benefits that our current severance and change-in-control arrangements provide are proportionate to the value brought to Idenix by each of the executives, and we believe our current severance and change-in-control benefits are appropriate.
 
We believe that the severance plans for executives are consistent with our goal of offering compensation packages that enable us to attract and retain talented executives on terms consistent with the interests of our shareholders.  While we do not believe that the provision of a severance plan is likely to be a determinative factor in an executive’s decision to join Idenix, the absence of such a plan could present a distinct competitive disadvantage in the market for talented executives.
 
Severance Payments
 
In the event that we terminate the employment of Drs. Mayers or Standring or Messrs. Renaud or Weidenbruch for reasons other than cause (as defined in their respective employment agreements), or if Dr. Mayers or Messrs. Renaud or Weidenbruch terminates his respective employment for good reason (as defined in his respective employment agreement), each executive is entitled to receive the following:
 
 
·
a lump sum payment equivalent to one times the executive officer’s base salary at the time of termination and the greater of: (i) the current year target cash performance incentive; or (ii) the cash performance incentive earned in the year preceding the year in which the termination of employment occurs;
 
 
·
immediate vesting and exercisability of all outstanding equity awards; and
 
 
·
benefits continuation pursuant to the federal “COBRA” laws, and continued payment by Idenix of premiums for the executive officer (and the executive officer’s covered dependents) under the group health, dental, disability and life insurance coverage at the active employee rates for a period of 12 months subsequent to the date of termination.
 
In the event our board of directors terminates Dr. Sommadossi’s employment for reasons other than cause (as defined in his employment agreement), or he terminates his employment for good reason (as described in his employment agreement), the chief executive officer is entitled to receive the following:
 
 
·
a lump sum payment equivalent to two times his base salary at the time of termination;
 
 
·
two times the greater of: (i) his current year target cash performance incentive; or (ii) the cash performance incentive earned in the year preceding the year in which the termination of employment occurs;
 
 
·
immediate vesting and exercisability of all outstanding equity awards;
 
 
27

 

 
·
benefits continuation pursuant to the federal “COBRA” laws, and continued payment by Idenix of premiums for him (and his covered dependents) under the group health, dental, and life insurance coverage at the active employee rates for a period of 24 months subsequent to the date of termination; and
 
 
·
pro-rated annual target cash performance incentive amount and pro-rated target equity grant.
 
In addition, Dr. Sommadossi’s employment agreement provides for cash and noncash benefits upon a termination of employment for death or disability.
 
Change-in-Control Payments
 
We have designed our change-in-control policies to provide income continuity after a change-in-control that results in the executive being separated from the company.  Our policy in the case of change-in-control benefits has been to structure these as “double trigger” benefits.  In other words, the change-in-control does not itself trigger benefits; rather, benefits are paid only if the employment of the executive is terminated or the executive terminates his or her employment for good reason during a specified period after the change-in-control. We believe a “double trigger” benefit maximizes shareholder value because it prevents an unintended windfall to executives in the event of a friendly change-in-control, while still providing them appropriate incentives to cooperate in negotiating any change-in-control in which they believe they may lose their jobs.  Under the terms of the employment agreements with our named executive officers, if, within one year following a change in control of Idenix, an executive officer’s  employment is terminated without cause or if such officer terminates his or her employment for good reason, the officer is entitled to, in addition to any severance payment, an additional lump-sum payment in an amount equal to:
 
 
·
such officer’s annual   base salary; and
 
 
·
the greater of such officer’s target cash performance incentive amount or the cash incentive award earned in the year preceding the year in which the termination occurs.
 
Dr. Sommadossi is also entitled to receive gross up payments on any applicable benefits he receives relating to change-in-control payments. This means that Dr. Sommadossi will be compensated for excise taxes and associated penalties imposed by Section 4999 of the Internal Revenue Code of 1986, as amended (the Code) by paying gross up amounts on any applicable benefits he receives under his employment agreement. The agreements we have with our other named executive officers provide that the amount of severance benefits payable to such executive may be reduced by an amount such that the excise tax provisions of sections 280G and 4999 of the Internal Revenue Code of 1986 would not apply to such payments.  The severance benefits payable will only be so reduced if the net after tax amount that would be received by the executive is greater than the net after-tax amount that would have been received without such reduction.
 
Tax Considerations
 
The Internal Revenue Service, pursuant to Section 162(m) of the Code, generally disallows a tax deduction for compensation in excess of $1.0 million paid to our chief executive officer and to each other officer (other than our chief executive officer and our chief financial officer) whose compensation is required to be reported to our stockholders pursuant to the Exchange Act by reason of being among the three most highly paid executive officers.  Certain compensation, including qualified performance-based compensation, will not be subject to the deduction limit if certain requirements are met.  We periodically review the potential consequences of Section 162(m) and we generally intend to structure the performance-based portion of our executive compensation, where feasible, to comply with exemptions in Section 162(m) so that the compensation remains tax deductible to us.  However, the Compensation Committee may, in its judgment, authorize compensation payments that do not comply with exemptions in Section 162(m) when it believes that such payments are appropriate to attract and retain executive talent.

Summary
 
The Compensation Committee believes that our compensation programs are designed and administered in a manner consistent with its compensation philosophy and objectives.  We continually monitor these programs in recognition of the dynamic marketplace in which we compete for talent.  We intend to continue to emphasize pay-for-performance and equity-based incentive programs that reward executives for actual results and that are consistent with shareholder interests.


Narrative Disclosure of our Compensation Policies and Practices as They Relate to Risk Management

Our Compensation Committee does not believe that any risks arising from our employee compensation policies and practices are reasonably likely to have a material adverse effect on our company.  Our Compensation Committee believes that any such risks are mitigated by:

·
The multiple elements of our compensation packages, including base salary, annual bonus programs and equity awards that vest over multiple years and are intended to motivate employees to take a long-term view of our business.
·
The structure of our annual cash bonus program that is based on a number of different performance measures (including goals related to our drug candidates and related programs, our discovery program and objectives relating to our general operations of the company, such as budget control, forecasting and financial reporting) and, generally,  on both individual and corporate goals to avoid employees placing undue emphasis on any particular performance metric at the expense of other aspects of our business.
·
Individual performance targets that we believe are somewhat aggressive yet reasonable and should not require undue risk-taking to achieve.
·
Goals being set appropriately to avoid targets that, if not achieved, result in a large percentage loss of compensation;
·
Annual cash performance incentive awards for all employees are capped at two hundred percent (200%) of target amount; and
·
Multi-year vesting of our equity awards and our share ownership guidelines properly account for the time horizon of risk.

EXECUTIVE COMPENSATION
 
Compensation Summary
 
The following table contains information with respect to the compensation for fiscal 2009 of anyone serving as our principal executive officer and principal financial officer during 2009 and our three most highly compensated executive officers serving as executive officers at the end of the last completed fiscal year. We refer to the executive officers identified in this table as our “named executive officers”.
 
Summary Compensation Table

                           
Non-Equity
                 
                           
Incentive
                 
                     
Option
   
Plan
   
All Other
           
Name and
     
Salary
   
Bonus
     
Awards
   
Compensation
   
Compensation
       
Total
 
Principal Position
 
Year
 
($)(1)
   
($)
     
($)(2)
   
($)(3)
   
($)
       
($)
 
Jean-Pierre Sommadossi,
 
2009
  $ 580,000       -       $ 647,780     $ 400,000     $ 30,987 (4)       $ 1,658,767  
President and CEO
 
2008
    575,000       -         1,019,375       400,000       29,569 (4)         2,023,944  
   
2007
    544,792       -         1,302,180       250,000       29,564 (4)         2,126,536  
Ronald C. Renaud, Jr.,
 
2009
    350,200       -         356,279       175,000       3,359 (6)         884,838  
Chief Financial Officer
 
2008
    348,500       -         233,000       200,000       -           781,500  
and Treasurer(5)
 
2007
    172,615     $ 400,000 (7)       803,382       74,333       -           1,450,330  
Douglas Mayers,
 
2009
    290,687       -         129,556       140,000       3,675 (9)         563,918  
Executive Vice President
 
2008
    325,000       -         233,000       150,000       3,450 (9)         711,450  
and Chief Medical Officer (8)
 
2007
    284,231       300,000 (10)       534,752       112,500       102,438 (11)         1,333,921  
David Standring,
 
2009
    260,000       -         145,751       105,000       3,315 (12)         514,066  
Executive Vice President,
 
2008
    260,000       -         203,875       91,000       3,082 (12)         557,957  
Biology
 
2007
    232,497                 149,519       63,450       2,703 (12)         448,169  
John F. Weidenbruch,
 
2009
    324,450       -         291,501       140,000       2964 (13)         758,915  
Executive Vice President,
 
2008
    322,875       -         174,750       130,000       2,388 (13)         630,013  
General Counsel and
 
2007
    311,875       -         98,330       82,688       79,532 (14)         572,425  
Secretary 
                                                         
 
(1)
Salary increases generally occur in March and are not retroactive to January. For this reason, the amount actually paid to the named executive officer is lower than such person’s base salary for the year.


(2)
The amounts in the Option Awards column reflect the grant date fair value of option awards granted during fiscal 2009 under our stock incentive plans, in accordance with FASB ASC Topic 718. There can be no assurance that FASB ASC Topic 718 amounts will reflect actual amounts realized. Refer to Note 10, “Equity Incentive Plans and Share-Based Compensation”, in the Notes to Consolidated Financial Statements included in the Annual Report on Form 10-K for fiscal 2009 filed with the SEC on March 9, 2010 for the relevant assumptions used to determine the valuation of our option awards.

(3)
The amounts shown in this column reflect cash bonus awards paid to our named executive officers under our annual performance-based incentive bonus plan for performance in the year indicated.

(4)
Consists of supplemental life insurance premiums paid by Idenix. Idenix paid for a life insurance policy for Dr. Sommadossi and grossed up such amounts as required pursuant to Dr. Sommadossi’s employment agreement.

(5)
Mr. Renaud became an executive officer of Idenix in June 2007.

(6)
Consists of amounts paid as a company match to Mr. Renaud’s 401(k).

(7)
Consists of a cash signing bonus in connection with the hiring of Mr. Renaud.

(8)
Dr. Mayers became an executive officer of Idenix in January 2007.

(9)
Consists of amounts paid as a company match to Dr. Mayers’ 401(k).
 
(10)
Consists of a cash signing bonus in connection with the hiring of Dr. Mayers.

(11)
Consists of amounts paid for Dr. Mayers’ relocation to the Boston, Massachusetts area including amounts required to gross up these expenses for tax purposes.

(12)
Consists of amounts paid as a company match to Dr. Standring’s 401(k).

(13)
Consists of amounts paid as a company match to Mr. Weidenbruch’s 401(k).

(14)
Consists of amounts paid for Mr. Weidenbruch’s relocation to the Boston, Massachusetts area including amounts required to gross up these expenses for tax purposes.
Grants of Plan-Based Awards
 
The following table shows information concerning each grant of an award made to a named executive officer during fiscal 2009 under any plan, contract, authorization or arrangement pursuant to which cash, securities, similar instruments or other property may be received.


Grants of Plan-Based Awards
 
                                           
All Other
                   
                                           
Option
               
Grant Date
 
                                           
Awards:
   
Exercise  or
   
Closing
   
Fair Value  of
 
       
Estimated Future Payouts Under
   
Estimated Future Payouts Under
   
Number of
   
Base  Price
   
Price of
   
Stock and
 
       
Non-Equity Incentive Plan Awards(1)
   
Equity Incentive Plan Awards(2)
   
Securities
   
of Option
   
Stock on
   
Option
 
       
Threshold
   
Target
   
Maximum
   
Threshold
   
Target
   
Maximum
   
Underlying
   
Awards
   
Grant
   
Awards
 
Name
 
Grant Date
 
($)
   
($)
   
($)
   
(#)
   
(#)
   
(#)(3)
   
Options (#)
   
($/Sh) (4)
   
Date ($)
   
($)(5)
 
Jean-Pierre Sommadossi
 
2/13/2009
  $ -     $ 348,000     $ 696,000                                                  
   
2/13/2009
                            -       300,000       -                          
   
2/13/2009
                                                    200,000     $ 5.46     $ 5.39     $ 647,780  
Ronald C. Renaud, Jr.
 
2/13/2009
    -       175,100       350,200                                                          
   
2/13/2009
                            -       80,000       -                                  
   
2/13/2009
                                                    110,000     $ 5.46     $ 5.39       356,279  
Douglas Mayers
 
2/13/2009
    -       165,000       330,000                                                          
   
2/13/2009
                            -       40,000       -                                  
   
2/13/2009
                                                    40,000     $ 5.46     $ 5.39       129,556  
David Standring
 
2/13/2009
    -       91,000       182,000                                                          
   
2/13/2009
                            -       30,000       -                                  
   
2/13/2009
                                                    45,000     $ 5.46     $ 5.39       145,751  
John Weidenbruch
 
2/13/2009
    -       113,558       227,116                                                          
   
2/13/2009
                            -       80,000       -                                  
   
2/13/2009
                                                    90,000     $ 5.46     $ 5.39       291,501  
 
(1)
Consists of potential cash payments under our annual performance-based incentive bonus plan for executives. Actual cash bonus amounts awarded in March 2010 for 2009 performance are set forth in the Summary Compensation Table above under the column entitled “Non-Equity Incentive Plan Compensation” for 2009.
 
(2)
Consists of potential stock option awards for executives under our annual performance-based incentive bonus plan for executives. For such stock option awards, the grant date fair value, in accordance with FASB ASC Topic 718, is set forth in the Summary Compensation Table under the column “Option Awards” for 2009.
 
(3)
No set maximum exists for equity incentive plan awards. Actual equity incentive plan awards are made at the discretion of our Compensation Committee or, in the case of awards to our chief executive officer, at the discretion of our board of directors based upon the Compensation Committee’s recommendation.
 
(4)
The exercise price of a share of our common stock on a particular date for purposes of granting stock options is determined as the average of the open and close prices as reported on the NASDAQ Global Market on such date.
   
(5)
The amounts in this column represent the grant date fair value of each equity award as determined in accordance with FASB ASC Topic 718. These amounts do not include the grant date fair value of equity awards calculated under FASB ASC Topic 718 of stock option awards granted in February 2010 under our 2009 annual performance-based incentive plan for executives.
 
 
The following table shows information regarding unexercised stock options held by our named executive officers as of December 31, 2009.

 
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Outstanding Equity Awards at Fiscal Year-End
 
   
Option Awards
         
Number of
         
   
Number of
   
Securities
         
   
Securities
   
Underlying
         
   
Underlying
   
Unexercised
   
Option Exercise
   
   
Unexercised Options
   
Options (#)
   
Price
 
Option Expiration
Name
 
(#)   Exercisable(1)
   
Unexercisable(1)
   
($)
 
Date
                     
Jean-Pierre Sommadossi
    56,250           $ 8.50  
11/19/2012
      100,000             12.05  
2/1/2014
      145,313       4,687       19.14  
2/27/2015
      117,188       32,812       21.11  
3/6/2016
      89,064       60,936       7.25  
3/28/2017
      100,000       50,000       7.24  
5/31/2017
      46,875       53,125       2.41  
11/8/2017
      147,659       202,341       5.18  
2/21/2018
            200,000       5.46  
2/13/2019
Ronald C. Renaud, Jr. 
    145,313       79,687       6.12  
6/27/2017
      21,667       18,333       2.41  
11/8/2017
      38,334       41,666       5.18  
2/21/2018
      25,209       84,791       5.46  
2/13/2019
Douglas Mayers
    75,000       25,000       8.88  
1/21/2017
      21,667       18,333       2.41  
11/8/2017
      38,334       41,666       5.18  
2/21/2018
      9,167       30,833       5.46  
2/13/2019
 David Standring
    5,000             8.50  
11/19/2012
      20,000             12.05  
2/1/2014
      20,000             19.14  
2/27/2015
      19,166       834       21.11  
3/6/2016
      17,708       7,292       8.12  
3/5/2017
      16,250       13,750       2.41  
11/8/2017
      33,542       36,458       5.18  
2/21/2018
      10,313       34,687       5.46  
2/13/2019
John Weidenbruch
    62,500       12,500       10.25  
9/4/2016
      7,084       2,916       8.12  
3/5/2017
      21,667       18,333       2.41  
11/8/2017
      28,750       31,250       5.18  
2/21/2018
      20,625       69,375       5.46  
2/13/2019
 
(1)
Options vest in 48 equal monthly installments beginning on the last day of the month of the date of grant, except that options granted to Dr. Sommadossi generally vest over a five-year period with 25% of the shares vesting on the first anniversary of the date of grant and the remaining 75% vesting in 48 equal monthly installments thereafter. Options exercisable set forth herein, if exercised, would provide voting power with respect to the shares of common stock underlying such options.
 

The following table sets forth certain information regarding the exercise of stock options during 2009 for each of the named executive officers:

OPTION EXERCISES DURING FISCAL 2009

   
Number of
Shares
Acquired Upon
Exercise (#)
   
Value Realized
Upon Exercise
($)(1)
 
             
Jean-Pierre Sommadossi
        $  
Ronald C. Renaud, Jr. 
        $  
Douglas Mayers
        $  
David Standring
    15,000     $ 12,900  
John Weidenbruch
          $  

(1)
Value represents the difference between the closing price per share of our common stock on each date of exercise and the exercise price per share, multiplied by the number of shares acquired on exercise.
Potential Payments Upon Termination or Change in Control
 
Potential payments made to our named executive officers in the instance of a termination without cause or a termination for good reason or in the case of change in control benefits upon a “double trigger” are discussed in greater detail under “Compensation Discussion and Analysis” “— Severance and Change in Control Benefits”.


The table below sets forth the potential payments to our named executive officers assuming a termination event or a change in control event occurred as of December 31, 2009:
 
POTENTIAL TERMINATION PAYMENTS
 
         
Acceleration of
             
         
Vesting of
             
   
Salary and
   
Equity
   
Other
       
   
Bonus(1)
   
Awards(2)
   
Payments(3)
   
Total
 
                                 
Jean-Pierre Sommadossi
 
$
 1,960,000