Consolidated Balance Sheets [Abstract] ASSETS Assets [Abstract] Current assets: Assets, Current [Abstract] LIABILITIES AND STOCKHOLDERS' EQUITY Liabilities and Stockholders' Equity [Abstract] Current liabilities: Liabilities, Current [Abstract] Total assets Assets Debt issuance costs and other assets Debt issuance costs and other assets Debt issuance costs and other assets. Property and equipment, net Property, Plant and Equipment, Net, Total Property, Plant and Equipment, Net, Beginning Balance Property, Plant and Equipment, Net, Ending Balance Property, Plant and Equipment, Net Total current assets Assets, Current Prepaid expenses and other current assets Prepaid expenses and other current assets Prepaid expenses and other current assets. Total current assets Cash and Cash Equivalents, at Carrying Value Cash and cash equivalents at end of year Cash and cash equivalents at beginning of year Cash and Cash Equivalents, at Carrying Value, Total Cash and cash equivalents Liabilities and Stockholders' Equity Total liabilities and stockholders' equity Ending Balance Stockholders' Equity Attributable to Parent Beginning Balance Total stockholders' equity Accumulated deficit Retained Earnings (Accumulated Deficit), Beginning Balance Retained Earnings (Accumulated Deficit), Ending Balance Retained Earnings (Accumulated Deficit) Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated Other Comprehensive Income (Loss), Net of Tax, Ending Balance Accumulated Other Comprehensive Income (Loss), Net of Tax, Beginning Balance Accumulated Other Comprehensive Income (Loss), Net of Tax, Total Accumulated other comprehensive income (loss) Additional paid-in capital Additional Paid in Capital, Common Stock, Beginning Balance Additional Paid in Capital, Common Stock, Ending Balance Additional Paid in Capital, Common Stock Common stock, $0.001 par value; 250,000,000 shares authorized, 145,233,948 and 131,125,690 shares issued and outstanding at December 31, 2010 and 2009, respectively Common Stock, Value, Issued Common Stock, Value, Issued, Ending Balance Common Stock, Value, Issued, Beginning Balance Common Stock, Value, Issued, Total Preferred stock, $0.001 par value; 10,000,000 shares authorized, no shares issued or outstanding Preferred Stock, Value, Issued, Total Preferred Stock, Value, Issued, Beginning Balance Preferred Stock, Value, Issued, Ending Balance Preferred Stock, Value, Issued Stockholders' equity: Stockholders' Equity Attributable to Parent [Abstract] Commitments and Contingencies Commitments and contingencies (Note 14) Capital lease obligations, less current portion Capital Lease Obligations, Noncurrent Total current liabilities Liabilities, Current, Total Liabilities, Current Current portion of facility lease obligation Current portion of facility lease obligations Current portion of facility lease obligation Current portion of facility lease obligation. Capital Lease Obligations, Current Current portion of capital lease obligations Accrued liabilities Accrued Liabilities, Current, Total Accrued Liabilities, Current Accounts payable Accounts Payable, Current, Total Accounts Payable, Current Preferred stock, par value Preferred Stock, Par or Stated Value Per Share Preferred stock, shares authorized Preferred Stock, Shares Authorized Preferred stock, shares issued Preferred Stock, Shares Issued, Total Preferred Stock, Shares Issued Preferred Stock, Shares Outstanding Preferred Stock, Shares Outstanding, Ending Balance Preferred Stock, Shares Outstanding, Beginning Balance Preferred stock, shares outstanding Common stock, par value Common Stock, Par or Stated Value Per Share Common stock, shares authorized Common Stock, Shares Authorized Common Stock, Shares, Issued Common Stock, Shares, Issued, Total Common stock, shares issued Common Stock, Shares, Outstanding Common Stock, Shares, Outstanding, Ending Balance Common Stock, Shares, Outstanding, Beginning Balance Common stock, shares outstanding Accrued compensation Employee-related Liabilities, Current, Total Employee-related Liabilities, Current Shares Used in Computation of Basic and Diluted Net Loss Per Share Shares used in computation of basic and diluted net loss per share Shares used in computation of basic and diluted net loss per share. Basic and diluted net loss per share Basic and diluted net loss per share Basic and diluted net loss per share. Net Income (Loss) Attributable to Parent Net loss Net loss Other income (expense): Nonoperating Income (Expense) [Abstract] Interest income Investment Income, Interest Operating Income (Loss) Operating Income (Loss), Total Loss from operations Research and development Research and Development Expense, Total Research and Development Expense Supplemental Cash Flow Information [Abstract] Supplemental Disclosure of Cash Flow Information: Cash and Cash Equivalents, Period Increase (Decrease) Cash and Cash Equivalents, Period Increase (Decrease), Total Net increase (decrease) in cash and cash equivalents Financing Activities: Net Cash Provided by (Used in) Financing Activities [Abstract] Net Cash Provided by (Used in) Financing Activities Net cash provided by financing activities Payments on Facility Lease Obligations Payments on facility lease obligations Payments on facility lease obligations. Payments on facility lease obligations Payments on long-term debt Repayments of Long-term Debt, Total Payments on long-term debt Repayments of Long-term Debt Proceeds From Release Of Security Deposit Associated Wth Debt Net proceeds from release of security deposits associated with debt Proceeds from release of security deposit associated with debt. Investing Activities: Net Cash Provided by (Used in) Investing Activities [Abstract] Net Cash Provided by (Used in) Investing Activities Net Cash Provided by (Used in) Investing Activities, Total Net cash used in investing activities Purchases of property and equipment Payments to Acquire Property, Plant, and Equipment Operating Activities: Net Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Changes in operating assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] Increase (Decrease) in Accrued Liabilities Accrued liabilities and compensation Accrued liabilities and compensation Accounts payable Increase (Decrease) in Accounts Payable, Total Increase (Decrease) in Accounts Payable Increase Decrease in Prepaid Antigen Costs Prepaid antigen costs Prepaid antigen costs Prepaid antigen costs. Share-based Compensation, Total Non-cash stock-based compensation expense Share-based Compensation Purchases of property and equipment Consolidated Statements of Operations [Abstract] Consolidated Statements of Cash Flows [Abstract] Net Cash Provided by (Used in) Operating Activities Net cash used in operating activities Commitments and Contingencies [Abstract] Commitments and Contingencies. COMMITMENTS AND CONTINGENCIES Commitments and Contingencies Disclosure [Text Block] Fair Value Measurements [Abstract] Fair Value Measurements. FAIR VALUE MEASUREMENTS Fair Value Disclosures [Text Block] PROPERTY AND EQUIPMENT Property, Plant and Equipment Disclosure [Text Block] INVESTMENTS Available-for-sale Securities [Text Block] Organization and Summary of Significant Accounting Policies [Abstract] Summary of Significant Accounting Policies. Significant Accounting Policies [Text Block] ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Stockholders' Equity Note Disclosure [Text Block] STOCKHOLDERS' EQUITY Entity Registrant Name Entity Central Index Key Document Type Document Period End Date Amendment Flag Current Fiscal Year End Date Entity Well-known Seasoned Issuer Entity Voluntary Filers Entity Current Reporting Status Entity Filer Category Entity Public Float Entity Common Stock, Shares Outstanding Accrued Liabilities [Abstract] Short-term investments Available-for-sale Securities, Debt Securities, Current, Total Available-for-sale Securities, Debt Securities, Current Long-term investments Available-for-sale Securities, Debt Securities, Noncurrent Warrant liability Warrants and Rights Outstanding Convertible senior subordinated notes Convertible Subordinated Debt, Noncurrent Interest expense Interest Expense, Total Interest expense Interest Expense Loss from valuation of warrant liability (Loss) gain from valuation of warrant liability Loss (gain) on valuation of warrant liability Loss from valuation of warrant liability. Investments [Abstract] Property and Equipment [Abstract] Convertible Senior Subordinated Notes [Abstract] Payments to Acquire Investments Purchases of investments Payments to Acquire Investments, Total Purchases of investments Increase (Decrease) in Other Operating Liabilities Other long term liabilities Interest Paid Cash paid during the period for interest Assets Acquired Under Facility And Capital Leases Assets acquired under facility and capital leases. Assets acquired under facility and capital leases Asset Retirement Obligation, Period Increase (Decrease) Asset Retirement Obligation, Period Increase (Decrease), Total Increase in asset retirement obligation Document and Entity Information [Abstract] Document and Entity Information. Document Fiscal Year Focus Document Fiscal Period Focus Prepaid Antigen Costs Prepaid antigen costs. Prepaid antigen costs Investment Income, Net, Amortization of Discount and Premium Amortization of securities discount and premium Investment Income, Net, Amortization of Discount and Premium, Total Amortization of securities discount and premium Increase Decrease In Prepaid Expense And Other Assets Prepaid expenses and other assets Prepaid expenses and other assets Increase decrease in prepaid expense and other assets. Repayments of Capital Lease Obligations Payments on capital lease obligations Payments on capital lease obligations Repayments of Capital Lease Obligations. Net proceeds (payments) from exercise of stock options and other Net proceeds from exercise of stock options and other Net proceeds from exercise of stock options and other Net proceeds (payments) from exercise of stock options and other. Accrued Liabilities Disclosure Text Block ACCRUED LIABILITIES Accrued Liabilities Disclosure. Convertible Senior Subordinated Notes Text Block CONVERTIBLE SENIOR SUBORDINATED NOTES Convertible Senior Subordinated Notes. Operating Expenses [Abstract] Operating expenses: Operating Expenses Total operating expenses Stockholders' Equity [Abstract] Proceeds from Sale, Maturity and Collections of Investments Proceeds from Sale, Maturity and Collections of Investments, Total Maturities and sales of investments Depreciation, Depletion and Amortization Depreciation, Depletion and Amortization, Total Depreciation and amortization expense Issuance of common stock under Employee Stock Purchase Plan Issuance of common stock under the Employee Stock Purchase Plan Issuance of common stock under Employee Stock Purchase Plan The cash inflow associated with the amount received from holders to acquire the entity's shares under incentive and share awards other than stock option exercises. Revenues Revenue Revenues, Total Revenue Accrued Liabilities Noncurrent Long-term accrued liabilities AccruedLiabilitiesNoncurrent. General and Administrative Expense Selling, general and administrative Employee Benifit Plan [Abstract] Proceeds from Issuance or Sale of Equity Proceeds from Issuance or Sale of Equity, Total Proceeds from common stock offering, net of issuance costs Debt Conversion, Original Debt, Amount Conversion of debt into common stock Stock-based Compensation Plans [Abstract] Disclosure of Compensation Related Costs, Share-based Payments [Text Block] STOCK-BASED COMPENSATION PLANS Income Taxes [Abstract] Income Tax Disclosure [Text Block] INCOME TAXES Net Loss Per Share [Abstract] Earnings Per Share [Text Block] NET LOSS PER SHARE Pension and Other Postretirement Benefits Disclosure [Text Block] EMPLOYEE BENEFIT PLAN Quarterly Information (Unaudited) [Abstract] Quarterly Financial Information [Text Block] QUARTERLY INFORMATION (UNAUDITED) Exercise of stock options for cash and other Stock Issued During Period, Value, Stock Options Exercised Exercise of stock options for cash and other, Shares Stock Issued During Period, Shares, Stock Options Exercised Stock Issued During Period, Value, Employee Stock Purchase Plan Issuance of common stock under the Employee Stock Purchase Plan Stock Issued During Period, Shares, Employee Stock Purchase Plans Issuance of common stock under the Employee Stock Purchase Plan, Shares Stock Issued During Period, Value, New Issues Issuance of common stock (net of issuance cost of $2,550 and $26,663 for the years 2008 and 2009 respectively) Stock Issued During Period, Shares, New Issues Issuance of common stock (net of issuance cost of $2,550,and $26,663 for the years 2008 and 2009 respectively), Shares Stock Issued During Period, Value, Conversion of Convertible Securities Conversion of convertible debt Stock Issued During Period, Shares, Conversion of Convertible Securities Conversion of convertible debt, Shares Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures, Total Issuance of restricted stock grants, Shares Other Comprehensive Income, Unrealized Holding Gain (Loss) on Securities Arising During Period, Net of Tax Net unrealized gain on securities available-for-sale Shares Issued Ending Balance, Shares Beginning Balance, Shares Comprehensive Income, Net of Tax, Attributable to Parent Comprehensive loss Common Stock Common Stock Additional Paid-in Capital Additional Paid-in Capital Other Comprehensive Income (Loss) Other Comprehensive Income (Loss) Accumulated Deficit Accumulated Deficit Statement [Table] Statement, Equity Components [Axis] Equity Component [Domain] Parent [Member] Statement [Line Items] Statement of Stockholders' Equity [Abstract] Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition, Value Non-cash stock-based compensation expense Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs Common stock issuance cost Inventory, Net Inventory, Net, Total Inventory Cost of Revenue Cost of revenue Cost of revenue Gross Profit Gross Profit, Total Gross profit Income Tax Expense (Benefit) Income tax benefit Income tax benefit Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Extraordinary Items, Cumulative Effects of Changes in Accounting Principles, Noncontrolling Interest Net loss before income tax benefit Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Extraordinary Items, Cumulative Effects of Changes in Accounting Principles, Noncontrolling Interest, Total Net loss before income tax benefit Increase (Decrease) in Accounts Receivable Trade accounts receivable Trade accounts receivable Increase (Decrease) in Inventories Inventory Increase (Decrease) in Inventories, Total Inventory Proceeds From exercise of Warrant Proceeds from exercise of warrant. Proceeds from exercise of warrant Inventory [Abstract] Inventory Disclosure [Text Block] Inventory Prepaid Expenses [Abstract] Prepaid Expenses. Prepaid Expenses Text Block Prepaid Expenses. Prepaid Expenses Subsequent Events[ Abstract] Subsequent Events. Schedule of Subsequent Events [Text Block] Subsequent Events Accounts Receivable, Net, Current Accounts Receivable, Net, Current, Total Trade accounts receivable Exercise Of Warrants Exercise of warrant Exercise of Warrants. Facility Lease Obligations Less Current Portion Facility lease obligations, less current portion Facility lease obligations, less current portion. Adjustments, Noncash Items, to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities, Other Other Proceeds from Issuance of Warrants Proceeds from issuance of warrants Gains Losses On Conversion Of Debt Loss on conversion of debt Loss on debt conversion Gains losses on conversion of debt. Stock Issued During Period Shares Share Warrants Exercised Exercise of warrants, Shares Stock issued during period shares, share warrants exercised. Stock Issued During Period Value Share Warrants Exercised Exercise of warrants Stock issued during period value, share warrants exercised. Financing Obligations and Debt [Abstract] Financing Obligations and Debt. Financing Obligations and Debt Text Block FINANCING OBLIGATIONS AND DEBT Financing Obligations and Debt.