Document And Entity Information [Abstract] Document And Entity Information [Abstract] Statement [Table] Statement [Line Items] Document Type Amendment Flag Document Period End Date Document Fiscal Year Focus Document Fiscal Period Focus Entity Registrant Name Entity Central Index Key Current Fiscal Year End Date Entity Filer Category Entity Common Stock, Shares Outstanding Condensed Consolidated Balance Sheets [Abstract] Assets Abstract Assets Cash and cash equivalents Cash and cash equivalents at end of period Cash and cash equivalents at beginning of period Cash and Cash Equivalents, at Carrying Value, Total Marketable Securities Current Marketable securities Marketable securities Marketable securities, aggregate fair value Trade accounts receivable, net Accounts Receivable, Net, Current, Total Inventory Net Inventories Total inventories, net Deferred tax assets Deferred Tax Assets, Net, Current, Ending Balance Deferred Tax Assets, Net, Current, Beginning Balance Deferred Tax Assets, Net, Current, Total Prepaid expenses and other current assets Prepaid expenses and other current assets Total current assets Total current assets Property Plant And Equipment Net Property, Plant and Equipment, Net, Ending Balance Property, Plant and Equipment, Net, Beginning Balance Property, plant and equipment, net Property, Plant and Equipment, Net, Total Intangible Assets Net Excluding Goodwill Intangible assets, net Intangible assets Intangible assets Goodwill, net Balance at September 30, 2011 Balance at December 31, 2010 Goodwill Goodwill, Total Goodwill Deferred Tax Assets Net Noncurrent Deferred tax assets Deferred Tax Assets, Net, Noncurrent, Total Other assets Other assets Assets Total assets Liabilities And Stockholders Equity Abstract Liabilities and Stockholders' Equity Accounts payable Accounts Payable, Current, Total Accrued Liabilities Current Accrued expenses Accrued Liabilities, Current, Total Deferred revenue Deferred Revenue, Current, Total Convertible Notes Payable, Current Amount of senior notes outstanding Current portion of convertible notes Current portion of capital lease obligations Current portion of capital lease obligations Other current liabilities Other Liabilities, Current, Total Total current liabilities Total current liabilities Capital lease obligations, less current portion Convertible notes Convertible notes, less current portion Deferred Tax Liabilities Noncurrent Deferred tax liabilities Business Acquisition, Contingent Consideration, at Fair Value, Noncurrent Balance at end of period Balance at end of period Balance at beginning of period Contingent consideration Other liabilities Other liabilities Liabilities Total liabilities CommitmentsAndContingencies2009 Commitments and contingencies (Note 16) Stockholders' Equity: Preferred Stock Value Preferred Stock, Value, Issued, Ending Balance Preferred Stock, Value, Issued, Beginning Balance Preferred Stock, Value, Issued, Total Preferred stock, $0.0001 par value; 5,000 shares authorized, no shares issued or outstanding Common Stock Value Common Stock, Value, Issued, Ending Balance Common Stock, Value, Issued, Beginning Balance Common stock, $0.0001 par value; 290,000 shares authorized; 184,866 and 182,471 shares issued at September 30, 2011 and December 31, 2010, respectively Common Stock, Value, Issued, Total Common stock, $0.0001 par value; 145,000 shares authorized; 92,396 and 91,591 shares issued at March 31, 2011 and December 31, 2010, respectively Additional paid-in capital Additional Paid in Capital, Common Stock, Ending Balance Additional Paid in Capital, Common Stock, Beginning Balance Treasury stock, at cost Treasury stock, at cost Treasury Stock, Value, Ending Balance Treasury Stock, Value, Beginning Balance Accumulated other comprehensive income (loss) Accumulated Other Comprehensive Income (Loss), Net of Tax, Ending Balance Accumulated Other Comprehensive Income (Loss), Net of Tax, Beginning Balance Accumulated other comprehensive loss Accumulated Other Comprehensive Income (Loss), Net of Tax, Total Accumulated deficit Retained Earnings (Accumulated Deficit), Ending Balance Retained Earnings (Accumulated Deficit), Beginning Balance Accumulated deficit Stockholders' Equity Attributable to Parent Balance, value Balance, value Total stockholders' equity Liabilities and Stockholders' Equity Total liabilities and stockholders' equity Preferred stock, par value Preferred stock, shares authorized Preferred stock, shares issued Preferred Stock, Shares Issued, Total Preferred stock, shares outstanding Preferred Stock, Shares Outstanding, Ending Balance Preferred Stock, Shares Outstanding, Beginning Balance Common stock, par value Common stock, shares authorized Authorized shares Common stock, shares issued Common Stock, Shares, Issued, Total Condensed Consolidated Statements Of Operations [Abstract] Net product sales Sales Revenue, Goods, Net, Total Cost of sales Cost of Goods Sold, Total Operating expenses: Research and development Research and Development Expense, Total Selling, general and administrative Selling, general and administrative Business Combination, Acquisition Related Costs Acquisition-related costs Acquisition-related costs, total Costs related to the acquisition Amortization of Acquired Intangible Assets Amortization of purchased intangible assets Operating Expenses Total operating expenses Operating income Operating income Other income and expense: Investment income Interest expense Interest expense Interest Expense, Total Foreign currency gain (loss) Foreign Currency Transaction Gain (Loss), before Tax, Total Foreign currency loss Income before income taxes Income before income taxes Income tax provision (benefit) Provision for income taxes Income tax provision Income tax provision Net income Net income used for basic calculation Net income Net income Earnings Per Common Share [Abstract] Earnings per common share Basic Basic Diluted Diluted Shares used in computing net income per share. Shares Used In Computing Net Income Per Share Shares used in computing earnings per common share Weighted Average Number Of Shares Outstanding Basic Basic Shares used in computing earnings per common share-basic Shares used in computing earnings per common share-basic Weighted Average Number Of Diluted Shares Outstanding Diluted Shares used in computing earnings per common share-diluted Consolidated Statements Of Cash Flows [Abstract] Cash flows from operating activities: Adjustments to reconcile net income to net cash flows from operating activities: Depreciation and amortization Depreciation, Depletion and Amortization, Total Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability Change in fair value of contingent consideration Increase in fair value of contingent consideration Share-based compensation expense Share-based Compensation, Total Deferred Income Taxes And Tax Credits Deferred taxes Deferred taxes Marketable securities premium amortization Marketable securities premium amortization InvestmentIncomeNetAmortizationOfDiscountAndPremium Marketable securities premium amortization Investment Income, Net, Amortization of Discount and Premium, Total Unrealized foreign currency loss Unrealized foreign currency (gain) loss Unrealized foreign currency gain Currency translation adjustments Unrealized (gain) loss on forward contracts Losses on forward contracts Foreign Currency Transaction Gain (Loss), Realized Currency translation adjustments Currency translation adjustments Loss on disposal of property, plant and equipment Loss on disposal of property, plant and equipment Gain (Loss) on Sale of Property Plant Equipment, Total Changes in operating assets and liabilities, excluding the effect of acquisitions: Accounts receivable Accounts receivable Increase Decrease In Inventories Inventories Inventories Increase (Decrease) in Inventories, Total Increase Decrease Prepaid expenses and other assets Prepaid expenses and other assets Increase (Decrease) in Prepaid, Deferred Expense and Other Assets, Total Accounts payable and accrued expenses Increase (Decrease) in Accounts Payable and Accrued Liabilities, Total Increase Decrease In Deferred Revenue Deferred revenue Deferred revenue Net Cash Provided by (Used in) Operating Activities Net cash provided by operating activities Cash flows from investing activities: Purchases of marketable securities Purchases of marketable securities Payments to Acquire Marketable Securities, Total Proceeds from maturity or sale of marketable securities Proceeds from Sale and Maturity of Marketable Securities, Total Purchases of property, plant and equipment Purchases of property, plant and equipment Payments to Acquire Property, Plant, and Equipment, Total Payments To Acquire Intangible Assets Purchase of technology rights Purchase of technology rights Payments to Acquire Businesses, Net of Cash Acquired Payments for acquisitions of businesses, net of cash acquired Payments to Acquire Businesses, Net of Cash Acquired, Total Payments for acquisition of business, net of cash acquired Increase (Decrease) in Restricted Cash Increase in restricted cash Release of restricted cash (Increase) decrease in restricted cash Release of restricted cash Net Cash Provided by (Used in) Investing Activities Net cash used in investing activities Cash flows from financing activities: Payments under capital lease obligations Payments on capital leases Payments on capital leases Excess tax benefit from stock options Proceeds from Other Debt Proceeds from revolving credit facility Repayments of Other Debt Payments on revolving credit facility Payments on revolving credit facility Proceeds from Stock Options Exercised Net proceeds from the exercise of stock options Net Cash Provided by (Used in) Financing Activities Net cash provided by financing activities Effect of exchange rate changes on cash Effect of Exchange Rate on Cash and Cash Equivalents, Total Net change in cash and cash equivalents Net change in cash and cash equivalents Business Abstract Business [Abstract] Business, l Business Basis Of Presentation And Principles Of Consolidation [Abstract] Basis of Presentation and Principles of Consolidation, l Basis Of Presentation And Principles Of Consolidation Acquisitions [Abstract] Business Combination Disclosure [Text Block] Acquisitions Revenue and Accounts Receivable Revenue And Accounts Receivable [Abstract] Revenue and accounts receivable text block Revenue And Accounts Receivable [Text Block] Revenue And Accounts Receivable Inventories [Abstract] Inventory Disclosure TextBlock Inventories Intangible Assets [Abstract] Goodwill and Intangible Assets Disclosure [Text Block] Intangible Assets Comprehensive Income [Abstract] Comprehensive Income, label Comprehensive Income Debt [Abstract] Debt, l Debt Earnings Per Common Share Text Block Earnings Per Common Share Marketable Securities [Abstract] Marketable Securities [Text Block] Marketable Securities Derivative Instruments And Hedging Activities [Abstract] Derivative Instruments and Hedging Activities, l Derivative Instruments And Hedging Activities Share-Based Compensation [Abstract] Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Share-Based Compensation Fair Value Measurement [Abstract] Fair Value Measurement, l Fair Value Measurement Income Taxes [Abstract] Income Taxes, l Income Taxes Employee Benefit Plans [Abstract] Employee Benefit Plans, l Employee Benefit Plans Commitments And Contingencies [Abstract] Commitments and Contingencies, l Commitments And Contingencies Revenue and Accounts Receivable, l Revenue Accounts Receivable TextBlock Accounts Receivable Schedule of Business Acquisitions, by Acquisition [Table] Business Acquisition, Integration, Restructuring and Other Related Costs [Text Block] Acquisition-Related Costs Reconciliation of Upfront Payments to Total Purchase Price [Table Text Block] Reconciliation Of Upfront Payments To Total Purchase Price [Table Text Block] Reconciliation Of Upfront Payments To Total Purchase Price Schedule of Purchase Price Allocation [Table Text Block] Purchase Price Allocation To Assets Acquired And Liabilities Assumed Business Acquisition, Pro Forma Information [Table Text Block] Pro Forma Financial Information Of Combined Results Of Operations Schedule of Inventory, Current [Table Text Block] Schedule Of Inventory, Current Schedule of Intangible Assets and Goodwill [Table Text Block] Schedule Of Carrying Amount Of Intangible Assets Schedule of Goodwill [Table Text Block] Schedule Of Changes In The Carrying Amount Of Goodwill Schedule of Comprehensive Income (Loss) [Table Text Block] Schedule Of Comprehensive Income Schedule of basic and diluted earnings per share table text block Schedule Of Basic And Diluted Earnings Per Share [Table Text Block] Summary Of Calculation Of Basic And Diluted Earnings Per Share Dilutive Shares Excluded from the Calculation of EPS Dilutive Shares Excluded From Calculation Of Earnings Per Share Available-for-sale Securities [Table Text Block] Schedule Of Marketable Securities Schedule of other comprehensive income and earnings from foreign exchange contracts Schedule of Other Comprehensive Income and Earnings from Foreign Exchange Contracts Text Block Schedule Of Other Comprehensive Income And Earnings From Foreign Exchange Contracts Schedule of fair value of outstanding derivatives Schedule of Fair Value of Outstanding Derivatives Text Block Schedule Of Fair Value Of Outstanding Derivatives Schedule of components of share based compensation expense table text block Schedule Of Components Of Share Based Compensation Expense [Table Text Block] Schedule Of Components Of Share-Based Compensation Expense Schedule that sets forth the allocation of share-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. Schedule Of Share Based Compensation Capitalized To Inventory [Table Text Block] Schedule Of Share-Based Compensation Capitalized To Inventory Fair Value, Assets and Liabilities Measured on Recurring Basis, Valuation Techniques Schedule Of Assets And Liabilities Measured At Fair Value Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block] Schedule Of Acquisition-Related Contingent Consideration Schedule of provisions for income taxes and effective tax rates Schedule Of Provisions For Income Taxes And Effective Tax Rates Text Block Schedule Of Provision For Income Taxes And Effective Tax Rates ScheduleOfProvisionsForIncomeTaxesAndEffectiveTaxRatesTextBlock Components of Net Periodic Benefit Cost Components Of Net Periodic Benefit Cost Number of ultra rare and severe disorders Number of ultra rare and severe disorders Percent of common stock dividend. Percent Of Common Stock Dividend Percent of common stock dividend Finite-Lived Intangible Assets by Major Class [Axis] Finite-Lived Intangible Assets, Major Class Name [Domain] In Process Research And Development [Member] In Process Research And Development Member In-Process Research And Development [Member] Range [Axis] Range [Domain] Maximum [Member] Minimum [Member] Business Acquisition [Line Items] Business Acquisition, Cost of Acquired Entity, Cash Paid Upfront payment in accordance with agreement Initial payments on acquisition Business Acquisition, Contingent Consideration, Potential Cash Payment Contingent milestone payments Business Acquisition, Contingent Consideration, at Fair Value Estimated fair value of contingent consideration Fair value of contingent consideration Industrial index rate for discounting contingent consideration cash flows. Industrial Index Rate For Discounting Contingent Consideration Cash Flows Rate for discounting contingent consideration cash flows Finite-Lived Intangible Assets, Useful Life Purchased technology, estimated useful life (In years) Business Acquisition, Purchase Price Allocation, Intangible Assets Not Amortizable Non-amortizable intangible assets Business Acquisition, Purchase Price Allocation, Intangible Assets Not Amortizable, Total Rate of return on historical costs. Rate Of Return On Historical Costs Rate of return on historical costs Deferred Tax Liabilities Deferred Tax Liabilities, Total Deferred tax liability Deferred Tax Liabilities, Goodwill and Intangible Assets, Intangible Assets Deferred tax liability related to IPR&D Deferred Tax Assets, Tax Credit Carryforwards Deferred Tax Assets, Tax Credit Carryforwards, Total Deferred tax liability related to net operating losses and research credit carryovers Weighted cash flow discount rate for development milestone. Weighted cash flow discount rate for development milestone Weighted cash flow discount rate for development milestones Weighted cash flow discount rate for commercial milestone. Weighted cash flow discount rate for commercial milestone Weighted cash flow discount rate for commercial milestones Discount rate derived from estimated weighted average cost of capital. Present Value Discount Rate Present value discount rate Business acquisition, related costs to employees. Business Acquisition, Related Costs to Employees Separately-identifiable employee costs Business acquisition cost related to banking, legal, accounting, valuation. Business Acquisition Cost Related To Banking, Legal, Accounting, Valuation Professional fees Business acquisition, changes in the fair value of contingent consideration. Business Acquisition, Changes in the Fair Value of Contingent Consideration Changes in the fair value of contingent consideration Labor and Related Expense Separately-identifiable employee costs Labor and Related Expense, Total Expense related to employee payments Business Combination, Consideration Transferred Business Combination, Consideration Transferred, Total Total consideration transferred Business Acquisition, Cost of Acquired Entity, Purchase Price Net assets acquired Total consideration transferred Total purchase price Purchased Technology [Member] Purchased Technology Member Purchased Technology [Member] Business Acquisition, Purchase Price Allocation, Current Assets, Cash and Cash Equivalents Cash and cash equivalents Business Acquisition, Purchase Price Allocation, Amortizable Intangible Assets Intangible assets Business Acquisition, Purchase Price Allocation, Other Noncurrent Assets Other assets Business Acquisition, Purchase Price Allocation, Assets Acquired Assets acquired Assets acquired Business Acquisition, Purchase Price Allocation, Deferred Income Taxes, Asset (Liability), Net Deferred tax liability (net) Deferred tax liability (net) Business Acquisition, Purchase Price Allocation, Other Noncurrent Liabilities Other liabilities assumed Business Acquisition, Purchase Price Allocation, Current Liabilities, Total Other liabilities assumed Business Acquisition, Purchase Price Allocation, Liabilities Assumed Liabilities assumed Liabilities assumed Liabilities assumed Business Acquisition, Purchase Price Allocation, Goodwill Amount Business Acquisition, Purchase Price Allocation, Goodwill Amount, Total Goodwill Business Acquisition, Pro Forma Revenue Revenues Business Acquisition, Pro Forma Net Income (Loss) Net income Business Acquisition, Pro Forma Earnings Per Share, Basic Earning per common share, Basic Business Acquisition, Pro Forma Earnings Per Share, Diluted Earning per common share, Diluted Raw materials Inventory, Raw Materials, Total Work-in-process Finished goods Inventory, Finished Goods, Total Legal Entity [Axis] Entity [Domain] Taligen Therapeutics, Inc [Member] Taligen Therapeutics Inc Member Taligen Therapeutics, Inc [Member] Orphatec Pharmaceuticals GmbH [Member] Orphatec Pharmaceuticals Gmbh Member Orphatec Pharmaceuticals GmbH [Member] Finite-Lived Intangible Assets, Gross Finite-Lived Intangible Assets, Gross, Total Finite-lived intangible assets Indefinite-Lived Intangible Assets (Excluding Goodwill) Indefinite-lived intangible assets Indefinite-Lived Intangible Assets (Excluding Goodwill), Total Indefinite-lived intangible assets Goodwill, Acquired During Period Goodwill resulting from the acquisition Other Comprehensive Income (Loss), Pension and Other Postretirement Benefit Plans, Adjustment, Net of Tax Defined benefit pension plan activity, net of tax Other Comprehensive Income (Loss), Pension and Other Postretirement Benefit Plans, Adjustment, Net of Tax, Total Unrealized gain (loss) on hedging activities, net of tax Unrealized gain on hedging activities Unrealized gain (loss) on hedge contracts, net of tax Net unrealized gain on available for sale securities, net of tax Other Comprehensive Income, Available-for-sale Securities Adjustment, Net of Tax, Total Net unrealized gain (loss) on available for sale securities, net of tax Foreign currency translation adjustment Other Comprehensive Income, Foreign Currency Transaction and Translation Adjustment, Net of Tax, Total Comprehensive income loss net of tax Comprehensive income Comprehensive income Schedule of Long-term Debt Instruments [Table] Long-term Debt, Type [Axis] Long-term Debt, Type [Domain] One Point Three Seven Five Point Convertible Serior Notes Due February Two Thouasand Twelve [Member] One Point Three Seven Five Point Convertible Serior Notes Due February Two Thouasand Twelve Member 1.375% Convertible Senior Notes Due February 2012 [Member] LIBOR Plus [Member] Libor Plus Member LIBOR Plus [Member] Federal Funds Rate [Member] Federal Funds Rate Member Federal Funds Rate [Member] Eurodollar Rate [Member] Eurodollar Rate Member Eurodollar Rate [Member] Debt Instrument [Line Items] Line of credit facility, maximum borrowing capacity Possible future increase in credit facility Possible future increase in credit facility Sublimit for letters of credit for working capital requirements and other general corporate purposes Sublimit for Letter of Credit for Working Capital Requirements and Other General Corporate Purposes Sublimit for letters of credit for working capital requirements and other general corporate purposes Debt Instrument, Interest Rate During Period Debt instrument, interest rate Line of Credit Facility, Expiration Date Principal maturity date Line of Credit Facility, Amount Outstanding Amount available for withdrawal under the revolving credit facility Letters of Credit Outstanding, Amount Letters of credit outstanding amount Line of Credit Facility, Remaining Borrowing Capacity Borrowing availability Debt Instrument, Periodic Payment, Principal Debt instrument, aggregate principal amount Shares Of Conversion Rights With Respect To An Aggregate Principal Amount Additional shares of common stock issued for a conversion of principal amount of 1.375% notes Debt Instrument, Interest Rate, Stated Percentage Interest rate of convertible senior notes Interest on Convertible Debt, Net of Tax Interest expense and debt financing cost amortization, net of tax, related to our 1.375% convertible senior notes Net income used for diluted calculation Net income used for diluted calculation Weighted Average Number of Shares, Contingently Issuable Shares issuable upon the assumed conversion of our 1.375% convertible senior notes Share-based Compensation Arrangement by Share-based Payment Award, Shares Issued in Period Stock awards Incremental Common Shares Attributable to Share-based Payment Arrangements, Total Weighted Average Number Diluted Shares Outstanding Adjustment Dilutive potential common shares Dilutive potential common shares Anti-dilutive Options to Purchase common stock Options to purchase common stock Anti-Dilutive Unvested Restricted Stock Anti-Dilutive Unvested Restricted Stock Unvested restricted stock Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Dilutive potential common shares Total potentially dilutive securities Schedule of Investment Income, Reported Amounts, by Category [Table] Schedule of Investment Income, Reported Amounts, by Category [Line Items] Available-for-sale Securities, Amortized Cost Basis Marketable securities, amortized cost basis Available-for-sale Securities, Amortized Cost Basis, Total Available-for-sale Securities, Gross Unrealized Gains Marketable securities, gross unrealized holding gains Available-for-sale Securities, Gross Unrealized Gains, Total Available-for-sale Securities, Gross Unrealized Losses Marketable securities, gross unrealized holding losses Marketable securities, Gross Unrealized Losses Available-for-sale Securities, Gross Unrealized Losses, Total Other than Temporary Impairment Losses, Investments, Available-for-sale Securities Marketable securities, other than temporary impairments Other than Temporary Impairment Losses, Investments, Available-for-sale Securities, Total Available-for-sale Securities, Gross Unrealized Gain (Loss) Marketable securities, realized gains and losses Available-for-sale Securities, Gross Unrealized Gain (Loss), Total Foreign exchange forward contracts durations Foreign exchange forward contracts durations Foreign exchange forward contracts durations (months), months Notional Amount of Cash Flow Hedge Instruments Cash flow hedges notional amounts Derivative Instruments, Gain (Loss) Reclassification from Accumulated OCI to Income, Estimated Net Amount to be Transferred Reclassified loss on other comprehensive income Foreign exchange forward contracts durations (days) Foreign exchange forward contracts durations (days) Notional amount of foreign exchange contracts that do not qualify for hedge accounting Notional amount of foreign exchange contracts that do not qualify for hedge accounting Gain (Loss) on Fair Value Hedges Recognized in Earnings (Loss) gain in other income and expense Gain (Loss) on Fair Value Hedges Recognized in Earnings, Total Derivative Instruments, Gain (Loss) Recognized in Other Comprehensive Income, Effective Portion, Net (Loss) gain recognized in OCI, net of tax Derivative Instruments, Gain (Loss) Recognized in Other Comprehensive Income, Effective Portion, Net, Total Derivative Instruments, Gain (Loss) Reclassified from Accumulated OCI into Income, Effective Portion, Net (Loss) gain reclassified from OCI to net product sales (Effective portion) Derivative Instruments, Gain (Loss) Reclassified from Accumulated OCI into Income, Effective Portion, Net, Total Derivative Instruments, Gain (Loss) Recognized in Income, Ineffective Portion and Amount Excluded from Effectiveness Testing, Net (Loss) gain reclassified from OCI to other income and expense (Ineffective portion) Derivative Instruments, Gain (Loss) Recognized in Income, Ineffective Portion and Amount Excluded from Effectiveness Testing, Net, Total Fair Values Derivatives, Balance Sheet Location, by Derivative Contract Type [Table] Hedging Designation [Axis] Hedging Designation [Domain] Derivatives Designated As Hedging Instruments [Member] Derivatives Not Designated As Hedging Instruments [Member] Derivatives, Fair Value, by Balance Sheet Location [Axis] Balance Sheet Location [Domain] Other Current Assets [Member] Other Current Assets Member Other Current Assets [Member] Other Non-Current Asset [Member] Other Non Current Asset Member Other Non-Current Assets [Member] Other Current Liabilities [Member] Other Current Liabilities Member Other Current Liabilities [Member] Other non-current liabilities Other Non Current Liabilities Member Other Non-Current Liabilities [Member] Investment Type [Axis] Investment Type [Domain] Other than Securities Investment [Member] Derivative [Member] Foreign Exchange Forward Contracts [Member] Derivatives, Fair Value [Line Items] Asset Derivatives, Fair Value Derivatives designated as hedging instruments, asset, fair value Derivative Asset, Fair Value, Total Liability Derivatives, Fair Value Derivatives designated as hedging instruments, liability, fair value Derivative Liability, Fair Value, Total Share Based Compensation Expense [Table] Share Based Compensation Expense [Table] Share-Based Compensation Expense [Table] Component of Other Operating Cost and Expense, General [Axis] Component of Other Operating Cost and Expense, Name [Domain] Research And Development [Member] Selling, General And Administrative [Member] Share Based Compensation Expense [Line Items] Share Based Compensation Expense [Line Items] Allocated share-based compensation expense Total share-based compensation expense Share-based Compensation Expense, Total Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost Share-based compensation expense capitalized to inventory Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Table] Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation, by Asset Type [Axis] Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation, Asset Types [Domain] Cash and Cash Equivalents [Member] Cash Equivalents [Member] Institutional Money Market Funds [Member] Investments [Member] Securities (Assets) [Member] Debt Securities [Member] US Treasury and Government [Member] Federal Agency Obligations [Member] U.S. Corporate Bonds [Member] Acquisition-Related Contingent Consideration [Member] Acquisition Related Contingent Consideration Member Acquisition-Related Contingent Consideration [Member] Fair Value, Assets Measured on Recurring Basis, Disclosure Items [Axis] Fair Value, Assets Measured on Recurring Basis, Disclosure Items [Domain] Level 1 [Member] Level 2 [Member] Level 3 [Member] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Assets Measured on Recurring Basis, Cash and Cash Equivalents Cash equivalents Available-for-sale Securities, Fair Value Disclosure Marketable securities Marketable securities, Aggregate Fair Value Fair value assets measured on recurring basis other current assets Fair value assets measured on recurring basis other current assets Other current assets Fair value assets measured on recurring basis other assets Fair value assets measured on recurring basis other assets Other assets Fair value liabilities measured on recurring basis other current liabilities Fair value liabilities measured on recurring basis other current liabilities Other current liabilities Fair value liabilities measured on recurring basis other liabilities Fair value liabilities measured on recurring basis other liabilities Other liabilities Fair Value Liabilities Measured On Recurring Basis Contingent Consideration Fair Value Liabilities Measured On Recurring Basis Contingent Consideration Contingent consideration Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset Value Balance at end of period Balance at beginning of period Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Purchases, Sales, Issuances, Settlements Amounts acquired or issued Amounts acquired or issued Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Purchases, Sales, Issuances, Settlements, Total Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Period Increase (Decrease) Change in fair value Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Period Increase (Decrease), Total Income Taxes [Table] Income Taxes [Table] Tax Credits By Type [Axis] Tax Credits By Type [Axis] Tax Credits By Type [Domain] Tax Credits By Type [Domain] Federal Foreign Tax And Orphan Drug Credit [Member] Federal Foreign Tax And Orphan Drug Credit Member Federal Foreign Tax And Orphan Drug Credit [Member] Orphan Drug Credit [Member] Orphan Drug Credit Member Orphan Drug Credit [Member] Income Taxes [Line Items] Income Taxes [Line Items] Effective Income Tax Rate, Continuing Operations Effective tax rate Effective Income Tax Rate, Continuing Operations, Total Amount Of Each Dollar Matching Contributed Up To First Four Percent Of Individual Base Salary And Incentive Cash Bonus Amount Of Each Dollar Matching Contributed Up To First Four Percent Of Individual Base Salary And Incentive Cash Bonus Amount matched for each dollar contributed up to first four percent of individual's base salary and incentive cash bonus Percentage of contribution of individual's base salary and incentive cash bonus. Percentage Of Contribution Of Individual's Base Salary And Incentive Cash Bonus Percentage of contribution of individual's base salary and incentive cash bonus Amount of each dollar matching contributed of next two percent of individual base salary and incentive cash bonus Amount Of Each Dollar Matching Contributed Of Next Two Percent Of Individual Base Salary And Incentive Cash Bonus Amount of each dollar matching contributed of next two percent of individual base salary and incentive cash bonus Percentage of contribution of compensation. Percentage Of Contribution Of Compensation Percentage of contribution of compensation Defined Contribution Plan, Cost Recognized Defined benefit plan, contributions by employer Service cost Interest cost Expected return on plan assets Expected return on plan assets Defined benefit plan amortization of gains losses Amortization Amortization Defined Benefit Plan, Contributions by Plan Participants Employee contribution Employee contribution DefinedBenefitPlanNetPeriodicBenefitCost Total net periodic benefit cost Accrued Royalties Accrued expenses for royalties Unrecorded Unconditional Purchase Obligation Approximate remaining total commitments through 2018 Unrecorded Unconditional Purchase Obligation, Total Business Acquisition [Axis] Business Acquisition, Acquiree [Domain] Schedule of Investment Income, Reported Amounts, by Category [Axis] Commercial Paper [Member] Corporate Bonds [Member] Cost Of Sales [Member]